The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Pilot controlled trial of d-serine for the treatment of post-traumatic stress disorder
Abstract
Enhancement of neurotransmission mediated at N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) may be beneficial in post-traumatic stress disorder (PTSD). d-serine (DSR) is an endogenous full agonist at the NMDAR-associated glycine modulatory site. Twenty-two chronic PTSD outpatients were randomly assigned to participate in a 6-wk double-blind, placebo-controlled, crossover trial with 30 mg/kg x d DSR used as monotherapy or add-on pharmacotherapy. Outcome was assessed using the Clinician-Administered PTSD scale (CAPS), Hamilton Anxiety (HAMA) and Depression (HAMD) scales and the civilian version of the Mississippi Scale for Combat-Related PTSD (MISS). DSR treatment was well tolerated and resulted in significantly (p=0.03) increased DSR serum levels. Compared with placebo administration, DSR treatment resulted in significantly reduced HAMA (p=0.007) and MISS (p=0.001) scores and a trend (p=0.07) towards improved CAPS total scores. These preliminary findings indicate that NMDAR glycine site-based pharmacotherapy may be effective in PTSD and warrant larger-sized clinical trials with optimized DSR dosages.
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Cites
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The development of a Clinician-Administered PTSD Scale
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A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy
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Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder
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“Previously we assessed in a pilot controlled 4-wk study the effects of DCS (50 mg/d) used as adjuvant to ongoing drug treatment in PTSD (Heresco-Levy et al. 2002).”
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Cited by
Response Variation following Trauma: A Translational Neuroscience Approach to Understanding PTSD
Yehuda, R., & LeDoux, J. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.006 · Cited by 783
Pharmacotherapy for post traumatic stress disorder (PTSD)
Stein, D. J., Ipser, J. C., Seedat, S., Sager, C., & Amos, T. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002795.pub2 · Cited by 519
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Garakani, A., Murrough, J. W., Freire, R. C., Thom, R. P., Larkin, K., Buono, F. D., & Iosifescu, D. V. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.595584 · Cited by 440
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390
Extending animal models of fear conditioning to humans
Delgado, M. R., Olsson, A., & Phelps, E. A. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.006 · Cited by 366
Metadata
- Authors
- Heresco-Levy, U., Vass, A., Bloch, B., Wolosker, H., Dumin, E., Balan, L., Deutsch, L., & Kremer, I.
- Venue
- International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-10
- Volume
- 12
- Issue
- 9
- Pages
- 1275-1282
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2100590082
- Cited by
- 169
- References
- 8
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pilot controlled trial of d-serine for the treatment of post-traumatic stress disorder. https://app.cochat.ai/papers/10.1017/s1461145709000339
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- Heresco-Levy, U., Vass, A., Bloch, B., Wolosker, H., Dumin, E., Balan, L., Deutsch, L., & Kremer, I. (2009). Pilot controlled trial of d-serine for the treatment of post-traumatic stress disorder. International Journal of Neuropsychopharmacology. https://doi.org/10.1017/s1461145709000339
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
