The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction
Open accessAbstract
Human depression is associated with cognitive deficits. It is critical to have valid animal models in order to investigate mechanisms and treatment strategies for these associated conditions. The goal of this study was to determine the association of cognitive dysfunction with depression-like behaviour in an animal model of depression and investigate the neural circuits underlying the behaviour. Mice that were exposed to social defeat for 14 d developed depression-like behaviour, i.e. anhedonia and social avoidance as indicated by reduced sucrose preference and decreased social interaction. The assessment of cognitive performance of defeated mice demonstrated impaired working memory in the T-maze continuous alternation task and enhanced fear memory in the contextual and cued fear-conditioning tests. In contrast, reference learning and memory in the Morris water maze test were intact in defeated mice. Neuronal activation following chronic social defeat was investigated by c-fosin-situ hybridization. Defeated mice exhibited preferential neural activity in the prefrontal cortex, cingulate cortex, hippocampal formation, septum, amygdala, and hypothalamic nuclei. Taken together, our results suggest that the chronic social defeat mouse model could serve as a valid animal model to study depression with cognitive impairments. The patterns of neuronal activation provide a neural basis for social defeat-induced changes in behaviour.
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“Chronic unpredictable/mild/variable stress and chronic social defeat stress are the two most commonly used animal models of depression [31, 34–38].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [37]
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Patki, G., Solanki, N., Atrooz, F., Allam, F., & Salim, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.033 · Cited by 380
The Anterior Cingulate Cortex Is a Critical Hub for Pain-Induced Depression
Barthas, F., Sellmeijer, J., Hugel, S., Waltisperger, E., Barrot, M., & Yalçın, İ. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.004 · Cited by 340
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Metadata
- Authors
- Yu, T., Guo, M., Garza, J., Rendon, S., Sun, X.-L., Zhang, W., & Lu, X.-Y.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Sichuan University (CN)
- Corresponding author
- Lu, Xin-Yun
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08-24
- Volume
- 14
- Issue
- 03
- Pages
- 303-317
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- PMC
- PMC3432579
- OpenAlex
- W1969190397
- Cited by
- 137
- References
- 81
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 13 · 2021: 4 · 2020: 14 · 2019: 10 · 2018: 15 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- China Scholarship Council
- National Institutes of Health
- National Institute of Mental Health (MH073844, MH076929, R01MH076929, R01MH073844)
- National Institute of Neurological Disorders and Stroke (NS056237, R03NS056237)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- chronic social defeat, depression-like behavior, cognitive impairment, working memory, fear memory, anhedonia, social avoidance, c-Fos neuronal activation, neural circuits, prefrontal cortex, hippocampus, amygdala, animal models of depression
- MeSH terms
- Animals, Brain, Cognition Disorders, Conditioning, Classical, Cues, Depression, Depressive Disorder, Disease Models, Animal, Emotions, Fear, Learning, Male, Memory, Short-Term, Mice, Inbred C57BL, RNA, Messenger, Social Behavior, Proto-Oncogene Proteins c-fos, Maze Learning, Models, Animal, Mice
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