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An Electrochemical Metalloimmunoassay Based on a Colloidal Gold Label
Abstract
A novel, sensitive electrochemical immunoassay has been developed using a colloidal gold label that, after oxidative gold metal dissolution in an acidic solution, was indirectly determined by anodic stripping voltammetry (ASV) at a single-use carbon-based screen-printed electrode (SPE). The use of disposable electrodes allows for simplified measurement in 35 microL of solution. The method was evaluated for a noncompetitive heterogeneous immunoassay of an immunoglobulin G (IgG) and a concentration as low as 3 x 10(-12) M was determined, which is competitive with colorimetric ELISA or with immunoassays based on fluorescent europium chelate labels. The high performance of the method is related to the sensitive ASV determination of gold(III) at a SPE (detection limit of 5 x 10(-9) M) and to the release of a large number of gold(III) ions from each gold particle anchored on the immunocomplex (e.g., 1.7 x 10(5) gold atoms are theoretically contained in a 18-nm spherical gold particle).
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Cited by
Electrochemical biosensors: Towards point-of-care cancer diagnostics
Wang, J. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.10.027 · Cited by 1,454
Hendel, T., Wuithschick, M., Kettemann, F., Birnbaum, A., Rademann, K., & Polte, J. (2014) · Analytical Chemistry · doi:10.1021/ac502053s · Cited by 235
Metadata
- Authors
- Dequaire, M., Degrand, C., & Limoges, B.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-10-21
- Volume
- 72
- Issue
- 22
- Pages
- 5521-5528
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2013113223
- Cited by
- 379
- References
- 0
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dequaire, M., Degrand, C., & Limoges, B. (2000). An Electrochemical Metalloimmunoassay Based on a Colloidal Gold Label. Analytical Chemistry. https://doi.org/10.1021/ac000781m
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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