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Simultaneous Multianalyte Detection with a Nanometer-Scale Pore
Abstract
It was recently shown that naturally occurring, genetically engineered or chemically modified channels can be used to detect analytes in solution. We demonstrate here that the overall range of analytes that can be detected by single nanometer-scale pores is expanded using a potentially simpler system. Instead of attaching recognition elements to a channel, they are covalently linked to polymers that otherwise thread through a nanometer-scale pore. Because the rate of unbound polymer entering the pore is proportional to its concentration in the bulk, the binding of analyte to the polymer alters the latter's ability to thread through the pore, and the signal that results from individual polymer translocation is unique to the polymer type; the method permits multianalyte detection and quantitation. We demonstrate here that two different proteins can be simultaneously detected with this technique.
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Citations
Cited by
DNA molecules and configurations in a solid-state nanopore microscope
Li, J., Gershow, M., Stein, D., Brandin, E., & Golovchenko, J. A. (2003) · Nature Materials · doi:10.1038/nmat965 · Cited by 936
Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore
Stoddart, D., Heron, A. J., Mikhailova, E., Maglia, G., & Bayley, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901054106 · Cited by 482
Single-molecule mass spectrometry in solution using a solitary nanopore
Robertson, J. W. F., Rodrigues, C. G., Stanford, V. M., Rubinson, K. A., Krasilnikov, O. V., & Kasianowicz, J. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611085104 · Cited by 364
Self-citationDigitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores
Bell, N. A. W., & Keyser, U. F. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.50 · Cited by 345
Translocation of Single-Stranded DNA Through Single-Walled Carbon Nanotubes
Liu, H., He, J., Tang, J., Liu, H., Pang, P., Cao, D., Krstic, P., Joseph, S., Lindsay, S., & Nuckolls, C. (2010) · Science · doi:10.1126/science.1181799 · Cited by 342
Metadata
- Authors
- Kasianowicz, J. J., Henrickson, S. E., Weetall, H. H., & Robertson, B.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-04-11
- Volume
- 73
- Issue
- 10
- Pages
- 2268-2272
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2089726088
- Cited by
- 193
- References
- 0
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kasianowicz, J. J., Henrickson, S. E., Weetall, H. H., & Robertson, B. (2001). Simultaneous Multianalyte Detection with a Nanometer-Scale Pore. Analytical Chemistry. https://doi.org/10.1021/ac000958c
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