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Passively Driven Integrated Microfluidic System for Separation of Motile Sperm
Abstract
This paper describes a self-contained integrated microfluidic system that can separate motile sperm from small samples that are difficult to handle using conventional sperm-sorting techniques. The device isolates motile sperm from nonmotile sperm and other cellular debris, based on the ability of motile sperm to cross streamlines in a laminar fluid stream. The device is small, simple, and disposable yet is an integrated system complete with sample inlets, outlets, sorting channel, and a novel passively driven pumping system that provides a steady flow of liquid; it requires no external power source or controls. The device fulfills a need in clinical settings where small amounts of sperm need to be sorted. It also opens the way for convenient bioassays based on sperm motility including at-home motile sperm tests.
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Citations
Cited by
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Microfluidics technology for manipulation and analysis of biological cells
Yi, C., Li, C.-W., Ji, S., & Yang, M. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2005.12.037 · Cited by 478
Microfluidics for flow cytometric analysis of cells and particles
Huh, D., Gu, W., Kamotani, Y., Grotberg, J. B., & Takayama, S. (2005) · Physiological Measurement · doi:10.1088/0967-3334/26/3/r02 · Cited by 396
Self-citationCombined microfluidic-micromagnetic separation of living cells in continuous flow
Xia, N., Hunt, T. P., Mayers, B. T., Alsberg, E., Whitesides, G. M., Westervelt, R. M., & Ingber, D. E. (2006) · Biomedical Microdevices · doi:10.1007/s10544-006-0033-0 · Cited by 371
Metadata
- Authors
- Cho, B. S., Schuster, T. G., Zhu, X., Chang, D., Smith, G. D., & Takayama, S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-02-22
- Volume
- 75
- Issue
- 7
- Pages
- 1671-1675
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2091904117
- Cited by
- 356
- References
- 0
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Passively Driven Integrated Microfluidic System for Separation of Motile Sperm. https://app.cochat.ai/papers/10.1021/ac020579e
- The paper
- Cho, B. S., Schuster, T. G., Zhu, X., Chang, D., Smith, G. D., & Takayama, S. (2003). Passively Driven Integrated Microfluidic System for Separation of Motile Sperm. Analytical Chemistry. https://doi.org/10.1021/ac020579e
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
