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Simultaneous Analysis of Multiple Classes of Antibiotics by Ion Trap LC/MS/MS for Assessing Surface Water and Groundwater Contamination
Abstract
Solid-phase extraction (SPE) and liquid chromatography in combination with ion trap mass spectrometry (LC/MS/MS) conditions were optimized for the simultaneous analysis of 13 antibiotics belonging to multiple classes and caffeine in 3 different water matrixes. The single-cartridge extraction step was developed using a reversed-phase cartridge, resulting in recoveries for the 14 compounds ranging from 71 to 119% with relative standard deviations of 16% or lower. The analytes were separated in one chromatographic run, and the SPE-LC/MS/MS detection limits ranged from 0.03 to 0.19 microg/L. The SPE procedure was validated in groundwater, surface water, and wastewater. The analysis of samples from each of the three water matrixes revealed clindamycin (1.1 microg/L) in surface water and multiple antibiotics in wastewater (0.10-1.3 microg/L). The use of identification points to unambiguously assign the identity of antibiotics in various water matrixes was applied to an ion trap data-dependent scanning method, which simultaneously collects full scan and full scan MS/MS data for the unequivocal identification of target analytes.
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Citations
Cited by
Antibiotics in the aquatic environment – A review – Part I
Kümmerer, K. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2008.11.086 · Cited by 4,475
Fluoroquinolone antibiotics: An emerging class of environmental micropollutants
Van Doorslaer, X., Dewulf, J., Van Langenhove, H., & Demeestere, K. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2014.08.075 · Cited by 819
Batt, A. L., Kim, S., & Aga, D. S. (2007) · Chemosphere · doi:10.1016/j.chemosphere.2007.01.008 · Cited by 542
Self-citationLin, A. Y.-C., & Tsai, Y.-T. (2009) · Science of The Total Environment · doi:10.1016/j.scitotenv.2009.03.009 · Cited by 406
An overview of analytical methodologies for the determination of antibiotics in environmental waters
Seifrtová, M., Nováková, L., Lino, C., Pena, A., & Solich, P. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2009.07.031 · Cited by 354
Metadata
- Authors
- Batt, A. L., & Aga, D. S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-03-31
- Volume
- 77
- Issue
- 9
- Pages
- 2940-2947
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2031521637
- Cited by
- 257
- References
- 0
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Batt, A. L., & Aga, D. S. (2005). Simultaneous Analysis of Multiple Classes of Antibiotics by Ion Trap LC/MS/MS for Assessing Surface Water and Groundwater Contamination. Analytical Chemistry. https://doi.org/10.1021/ac048512%2B
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