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Electrogenerated Chemiluminescence. 83. Immunoassay of Human C-Reactive Protein by Using Ru(bpy)32+-Encapsulated Liposomes as Labels
Abstract
Liposomes ( approximately 100-nm diameter) containing Ru(bpy)32+ (bpy = 2,2'-bipyridine) were prepared as an electrogenerated chemiluminescent (ECL) tag for a sandwich-type immunoassay of human C-reactive protein (CRP). Polyclonal human CRP antibodies were introduced onto liposomes and magnetic beads through biotin-streptavidin interaction. The antigen-antibody conjugates formed on addition of a CRP-containing sample were separated from unreacted species magnetically. Addition of 0.1 M tri-n-propylamine and 0.1 M phosphate buffer (pH 7.6) containing 0.1 M NaCl and 1% (v/v) Triton X-100 caused liberation of the Ru(bpy)32+ from the liposome. ECL obtained in this medium showed a detection limit of 100 ng/mL for human CRP with good linearity of ECL intensity versus antigen concentration over the range 100 ng/mL-10 microg/mL.
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The "Stealth" Liposome: A Prototypical Biomaterial
Lasic, D. D., & Needham, D. (1995) · Chemical Reviews · doi:10.1021/cr00040a001 · Cited by 416
Cited by
Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers
Chikkaveeraiah, B. V., Bhirde, A. A., Morgan, N. Y., Eden, H. S., & Chen, X. (2012) · ACS Nano · doi:10.1021/nn3023969 · Cited by 719
Jung, J. H., Lee, J. H., & Shinkai, S. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15051k · Cited by 273
Metadata
- Authors
- Zhan, W., & Bard, A. J.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-12-07
- Volume
- 79
- Issue
- 2
- Pages
- 459-463
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2015045640
- Cited by
- 162
- References
- 1
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Electrogenerated Chemiluminescence. 83. Immunoassay of Human C-Reactive Protein by Using Ru(bpy)32+-Encapsulated Liposomes as Labels. https://app.cochat.ai/papers/10.1021/ac061336f
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- Zhan, W., & Bard, A. J. (2007). Electrogenerated Chemiluminescence. 83. Immunoassay of Human C-Reactive Protein by Using Ru(bpy)32+-Encapsulated Liposomes as Labels. Analytical Chemistry. https://doi.org/10.1021/ac061336f
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