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Noninvasive Authentication of Pharmaceutical Products through Packaging Using Spatially Offset Raman Spectroscopy
Abstract
We demonstrate the use of spatially offset Raman spectroscopy (SORS) in the identification of counterfeit pharmaceutical tablets and capsules through different types of packaging. The technique offers a substantially higher sensitivity than that available from conventional backscattering Raman spectroscopy. The approach is particularly beneficial in situations where the conventional Raman backscattering method is hampered or fails because of excessive surface Raman or fluorescence signals emanating from the packaging, capsule shell, or tablet coating contaminating the much weaker subsurface Raman signals of the active pharmaceutical ingredients and excipients held in the product. It is demonstrated that such interfering signals can be effectively suppressed by SORS.
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Cited by
Raman spectroscopy: Recent advancements, techniques and applications
Das, R. S., & Agrawal, Y. K. (2011) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2011.08.003 · Cited by 773
Analytical applications of Raman spectroscopy
Kudelski, A. (2008) · Talanta · doi:10.1016/j.talanta.2008.02.042 · Cited by 455
Raman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Raman spectroscopy in pharmaceutical product design
Paudel, A., Raijada, D., & Rantanen, J. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.003 · Cited by 302
Raman Spectroscopy for Process Analytical Technologies of Pharmaceutical Secondary Manufacturing
Nagy, B., Farkas, A., Borbás, E., Vass, P., Nagy, Z. K., & Marosi, G. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-018-1201-2 · Cited by 89
Metadata
- Authors
- Eliasson, C., & Matousek, P.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01-18
- Volume
- 79
- Issue
- 4
- Pages
- 1696-1701
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2142367460
- Cited by
- 186
- References
- 0
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eliasson, C., & Matousek, P. (2007). Noninvasive Authentication of Pharmaceutical Products through Packaging Using Spatially Offset Raman Spectroscopy. Analytical Chemistry. https://doi.org/10.1021/ac062223z
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