The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rapid and Sensitive Detection of Protein Biomarker Using a Portable Fluorescence Biosensor Based on Quantum Dots and a Lateral Flow Test Strip
Abstract
A portable fluorescence biosensor with rapid and ultrasensitive response for protein biomarker has been built up with quantum dots and a lateral flow test strip. The superior signal brightness and high photostability of quantum dots are combined with the promising advantages of a lateral flow test strip and result in high sensitivity and selectivity and speed for protein detection. Nitrated ceruloplasmin, a significant biomarker for cardiovascular disease, lung cancer, and stress response to smoking, was used as model protein biomarker to demonstrate the good performances of this proposed quantum dot-based lateral flow test strip. Quantitative detection of nitrated ceruloplasmin was realized by recording the fluorescence intensity of quantum dots captured on the test line. Under optimal conditions, this portable fluorescence biosensor displays rapid responses for nitrated ceruloplasmin with the concentration as low as 1 ng/mL. Furthermore, the biosensor was successfully utilized for spiked human plasma sample detection in a wide dynamic range with a detection limit of 8 ng/mL (S/N = 3). The results demonstrate that the quantum dot-based lateral flow test strip is capable of rapid, sensitive, and quantitative detection of nitrated ceruloplasmin and hold a great promise for point-of-care and in field analysis of other protein biomarkers.
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Cites
Global Analysis of Protein Activities Using Proteome Chips
Zhu, H., Bilgin, M., Bangham, R., Hall, D., Casamayor, A., Bertone, P., Lan, N., Jansen, R., Bidlingmaier, S., Houfek, T., et al. (2001) · Science · doi:10.1126/science.1062191 · Cited by 1,884
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
Shiva, S., Wang, X., Ringwood, L. A., Xu, X., Yuditskaya, S., Annavajjhala, V., Miyajima, H., Hogg, N., Harris, Z. L., & Gladwin, M. T. (2006) · Nature Chemical Biology · doi:10.1038/nchembio813 · Cited by 359
Cited by
Huang, X., Aguilar, Z. P., Xu, H., Lai, W., & Xiong, Y. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.08.032 · Cited by 499
Integrated rapid-diagnostic-test reader platform on a cellphone
Mudanyali, O., Dimitrov, S., Sikora, U., Padmanabhan, S., Navruz, I., & Ozcan, A. (2012) · Lab on a Chip · doi:10.1039/c2lc40235a · Cited by 426
Zangheri, M., Cevenini, L., Anfossi, L., Baggiani, C., Simoni, P., Di Nardo, F., & Roda, A. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.08.048 · Cited by 373
Stress Biomarkers in Biological Fluids and Their Point-of-Use Detection
Steckl, A. J., & Ray, P. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00726 · Cited by 319
The application of nanoparticles in point-of-care testing (POCT) immunoassays
Hou, F., Sun, S., Abdullah, S. W., Tang, Y., Li, X., & Guo, H. (2023) · Analytical Methods · doi:10.1039/d3ay00182b · Cited by 61
Metadata
- Authors
- Li, Z., Wang, Y., Wang, J., Tang, Z., Pounds, J. G., & Lin, Y.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-07-19
- Volume
- 82
- Issue
- 16
- Pages
- 7008-7014
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2030785436
- Cited by
- 424
- References
- 2
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Z., Wang, Y., Wang, J., Tang, Z., Pounds, J. G., & Lin, Y. (2010). Rapid and Sensitive Detection of Protein Biomarker Using a Portable Fluorescence Biosensor Based on Quantum Dots and a Lateral Flow Test Strip. Analytical Chemistry. https://doi.org/10.1021/ac101405a
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