The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Highly Selective and Instantaneous Nanoprobe for Detection and Imaging of Ascorbic Acid in Living Cells and in Vivo
Abstract
The development of a specific reaction of nanomaterials and reactive species is of fundamental importance for the determination of biomolecules. Here we report a novel nanoprobe for detection and imaging of ascorbic acid (AA) in living cells and in vivo based on the specific reaction of cobalt oxyhydroxide (CoOOH) and AA. Persistent luminescence nanoparticles (PLNPs) were used as the luminescence unit, and CoOOH nanoflakes served as the quencher. When CoOOH was modified on the surface of the PLNPs, the luminescence of the PLNPs was efficiently quenched by the CoOOH. In the presence of AA, CoOOH was reduced to Co(2+) and the luminescence of PLNPs was restored. The nanoprobe showed high selectivity and an instantaneous response. The luminescence property permits detection and imaging without external excitation, which could effectively avoid background noise and scattering of light from biological matrixes produced by in situ excitation. The current strategy provides an effective platform for monitoring and imaging reactive species in living cells and in vivo.
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Cites
Targeting hypoxia in cancer therapy
Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172
Carr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940
Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804226105 · Cited by 854
Cited by
Long persistent phosphors—from fundamentals to applications
Li, Y., Gecevicius, M., & Qiu, J. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00582e · Cited by 1,368
Self-citationMolecular Probes for Autofluorescence-Free Optical Imaging
Jiang, Y., & Pu, K. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00506 · Cited by 426
Sun, S.-K., Wang, H.-F., & Yan, X.-P. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00619 · Cited by 384
Rong, M., Lin, L., Song, X., Wang, Y., Zhong, Y., Yan, J., Feng, Y., Zeng, X., & Chen, X. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.12.024 · Cited by 275
Zhu, X., Zhao, T., Nie, Z., Liu, Y., & Yao, S. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02167 · Cited by 265
Metadata
- Authors
- Li, N., Li, Y., Han, Y., Pan, W., Zhang, T., & Tang, B.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-04-01
- Volume
- 86
- Issue
- 8
- Pages
- 3924-3930
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2330405544
- Cited by
- 222
- References
- 3
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
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