The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Turn-On Fluorescence Sensor for Intracellular Imaging of Glutathione Using g-C3N4 Nanosheet–MnO2 Sandwich Nanocomposite
Abstract
Herein, a novel fluorescence sensor based on g-C3N4 nanosheet-MnO2 sandwich nanocomposite has been developed for rapid and selective sensing of glutathione (GSH) in aqueous solutions, as well as living cells. The graphitic-phase C3N4 (g-C3N4) nanosheet used here is a new type of carbon-based nanomaterial with high fluorescence quantum yield and high specific surface area. We demonstrate a facile one-step approach for the synthesis of a g-C3N4 nanosheet-MnO2 sandwich nanocomposite for the first time. The fluorescence of g-C3N4 nanosheet in this nanocomposite is quenched, which attributing to fluorescence resonance energy transfer (FRET) from a g-C3N4 nanosheet to the deposited MnO2. Upon the addition of GSH, MnO2 is reduced to Mn(2+), which leads to the elimination of FRET. As a result, the fluorescence of g-C3N4 nanosheet is restored. Importantly, the chemical response of the g-C3N4-MnO2 nanocomposite exhibits great selectivity toward GSH relative to other electrolytes and biomolecules. Under the optimal conditions, the detection limit of 0.2 μM for GSH in aqueous solutions can be reached. Furthermore, the g-C3N4-MnO2 nanocomposite is confirmed to be membrane-permeable and have low cytotoxicity. Moreover, we successfully apply this sensor for visualizing and monitoring change of the intracellular GSH in living cells. Moreover, the proposed sensor shows satisfying performance, such as low cost, easy preparation, rapid detection, good biocompatibility, and turn-on fluorescence response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Quantum dots versus organic dyes as fluorescent labels
Resch-Genger, U., Grabolle, M., Cavaliere-Jaricot, S., Nitschke, R., & Nann, T. (2008) · Nature Methods · doi:10.1038/nmeth.1248 · Cited by 3,833
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
Zhu, S., Meng, Q., Wang, L., Zhang, J., Song, Y., Jin, H., Zhang, K., Sun, H., Wang, H., & Yang, B. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201300519 · Cited by 3,720
Glutathione: overview of its protective roles, measurement, and biosynthesis
Forman, H. J., Zhang, H., & Rinna, A. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.006 · Cited by 2,636
Luminescent Chemodosimeters for Bioimaging
Yang, Y., Zhao, Q., Feng, W., & Li, F. (2013) · Chemical Reviews · doi:10.1021/cr2004103 · Cited by 2,236
Carbon Dots for Multiphoton Bioimaging
Cao, L., Wang, X., Meziani, M. J., Lu, F., Wang, H., Luo, P. G., Lin, Y., Harruff, B. A., Veca, L. M., Murray, D., et al. (2007) · Journal of the American Chemical Society · doi:10.1021/ja073527l · Cited by 2,174
Enhanced Photoresponsive Ultrathin Graphitic-Phase C3N4Nanosheets for Bioimaging
Zhang, X., Xie, X., Wang, H., Zhang, J., Pan, B., & Xie, Y. (2013) · Journal of the American Chemical Society · doi:10.1021/ja308249k · Cited by 2,136
Self-citationShen, J., Zhu, Y., Yang, X., & Li, C. (2012) · Chemical Communications · doi:10.1039/c2cc00110a · Cited by 2,071
A Graphene Platform for Sensing Biomolecules
Lu, C., Yang, H., Zhu, C., Chen, X., & Chen, G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901479 · Cited by 2,051
Self-citationThe importance of glutathione in human disease
Townsend, D. M., Tew, K. D., & Tapiero, H. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00043-x · Cited by 2,004
Blue Photoluminescence from Chemically Derived Graphene Oxide
Eda, G., Lin, Y., Mattevi, C., Yamaguchi, H., Chen, H., Chen, I., Chen, C., & Chhowalla, M. (2010) · Advanced Materials · doi:10.1002/adma.200901996 · Cited by 1,994
Cited by
Two-dimensional covalent carbon nitride nanosheets: synthesis, functionalization, and applications
Zhang, J., Chen, Y., & Wang, X. (2015) · Energy & Environmental Science · doi:10.1039/c5ee01895a · Cited by 1,011
Graphitic carbon nitride “reloaded”: emerging applications beyond (photo)catalysis
Liu, J., Wang, H., & Antonietti, M. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00767d · Cited by 930
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
Ding, B., Zheng, P., Ma, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.201905823 · Cited by 521
Biomedical Uses for 2D Materials Beyond Graphene: Current Advances and Challenges Ahead
Kurapati, R., Kostarelos, K., Prato, M., & Bianco, A. (2016) · Advanced Materials · doi:10.1002/adma.201506306 · Cited by 417
Rong, M., Lin, L., Song, X., Zhao, T., Zhong, Y., Yan, J., Wang, Y., & Chen, X. (2015) · Analytical Chemistry · doi:10.1021/ac5039913 · Cited by 334
Huang, H., Feng, W., & Chen, Y. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01138j · Cited by 285
Rong, M., Lin, L., Song, X., Wang, Y., Zhong, Y., Yan, J., Feng, Y., Zeng, X., & Chen, X. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.12.024 · Cited by 275
Metadata
- Authors
- Zhang, X.-L., Zheng, C., Guo, S.-S., Li, J., Yang, H.-H., & Chen, G.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-21
- Volume
- 86
- Issue
- 7
- Pages
- 3426-3434
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2326189006
- Cited by
- 414
- References
- 52
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
