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Fully Integrated Glass Microfluidic Device for Performing High-Efficiency Capillary Electrophoresis and Electrospray Ionization Mass Spectrometry
Open accessAbstract
A microfabricated device has been developed in which electrospray ionization is performed directly from the corner of a rectangular glass microchip. The device allows highly efficient electrokinetically driven separations to be coupled directly to a mass spectrometer (MS) without the use of external pressure sources or the insertion of capillary spray tips. An electrokinetic-based hydraulic pump is integrated on the chip that directs eluting materials to the monolithically integrated spray tip. A positively charged surface coating, PolyE-323, is used to prevent surface interactions with peptides and proteins and to reverse the electroosmotic flow in the separation channel. The device has been used to perform microchip CE-MS analysis of peptides and proteins with efficiencies over 200,000 theoretical plates (1,000,000 plates/m). The sensitivity and stability of the microfabricated ESI source were found to be comparable to that of commercial pulled fused-silica capillary nanospray sources.
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Citations
Cited by
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Advances in Microfluidic Materials, Functions, Integration, and Applications
Nge, P. N., Rogers, C. I., & Woolley, A. T. (2013) · Chemical Reviews · doi:10.1021/cr300337x · Cited by 958
Latest Developments in Micro Total Analysis Systems
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Metadata
- Authors
- Mellors, J. S., Gorbounov, V., Ramsey, R. S., & Ramsey, J. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-08-13
- Volume
- 80
- Issue
- 18
- Pages
- 6881-6887
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2084607518
- Cited by
- 198
- References
- 0
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Mellors, J. S., Gorbounov, V., Ramsey, R. S., & Ramsey, J. M. (2008). Fully Integrated Glass Microfluidic Device for Performing High-Efficiency Capillary Electrophoresis and Electrospray Ionization Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/ac800428w
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