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Nanomolar and Selective Determination of Epinephrine in the Presence of Norepinephrine Using Carbon Paste Electrode Modified with Carbon Nanotubes and Novel 2-(4-Oxo-3-phenyl-3,4-dihydro-quinazolinyl)-N′-phenyl-hydrazinecarbothioamide
Abstract
A novel modified carbon nanotube paste electrode of 2-(4-oxo-3-phenyl-3,4-dihydro-quinazolinyl)-N'-phenyl-hydrazinecarbothioamide (2PHC) was fabricated, and the electro-oxidation of epinephrine (EP), norepinephrine (NE), and their mixture has been studied using electrochemical methods. The modified electrode displayed strong catalytic function for the oxidation of EP and NE and resolved the overlap voltammetric response of EP and NE into two well-defined voltammetric peaks of about 240 mV with square wave voltammetry (SWV). A linear response in the range of (5 x 10(-8))-(5.5 x 10(-4)) M with a detection limit (S/N = 3) of 9.4 nM for EP was obtained.
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Cited by
Advances in carbon nanotube based electrochemical sensors for bioanalytical applications
Vashist, S. K., Zheng, D., Al-Rubeaan, K., Luong, J. H. T., & Sheu, F.-S. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.10.002 · Cited by 448
Electrochemical sensing based on carbon nanotubes
Yáñez-Sedeño, P., Pingarrón, J. M., Riu, J., & Rius, F. X. (2010) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2010.06.006 · Cited by 294
Dopamine biosensor based on surface functionalized nanostructured nickel oxide platform
Roychoudhury, A., Basu, S., & Jha, S. K. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.11.061 · Cited by 184
Metadata
- Authors
- Beitollahi, H., Karimi-Maleh, H., & Khabazzadeh, H.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-11-19
- Volume
- 80
- Issue
- 24
- Pages
- 9848-9851
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2087053953
- Cited by
- 483
- References
- 0
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Nanomolar and Selective Determination of Epinephrine in the Presence of Norepinephrine Using Carbon Paste Electrode Modified with Carbon Nanotubes and Novel 2-(4-Oxo-3-phenyl-3,4-dihydro-quinazolinyl)-N′-phenyl-hydrazinecarbothioamide. https://app.cochat.ai/papers/10.1021/ac801854j
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- Beitollahi, H., Karimi-Maleh, H., & Khabazzadeh, H. (2008). Nanomolar and Selective Determination of Epinephrine in the Presence of Norepinephrine Using Carbon Paste Electrode Modified with Carbon Nanotubes and Novel 2-(4-Oxo-3-phenyl-3,4-dihydro-quinazolinyl)-N′-phenyl-hydrazinecarbothioamide. Analytical Chemistry. https://doi.org/10.1021/ac801854j
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