The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Three-Dimensional Ion Mobility/TOFMS Analysis of Electrosprayed Biomolecules
Abstract
An ion mobility/mass spectrometry technique has been developed to record mass-resolved ion mobility distributions for multiple ions simultaneously. The approach involves a new instrument that couples an electrospray ion source to an injected-ion drift tube/time-of-flight mass spectrometer. Individual components in a mixture of ions are separated by mobility differences in a drift tube and subsequently dispersed by mass-to-charge ratios in a time-of-flight instrument. Flight times in the mass spectrometer are much shorter than residence times in the drift tube, making it possible to record mass-resolved ion mobilities for all ions simultaneously. The result is a three-dimensional spectrum that contains collision cross section, mass-to-charge, and ion abundance information. The instrument and data acquisition system are described. Examples of combined ion mobility/time-of-flight data are presented for distributions of electrosprayed bradykinin and ubiquitin ions.
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Citations
Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Cited by
Recommendations for reporting ion mobility Mass Spectrometry measurements
Gabelica, V., Shvartsburg, A. A., Afonso, C., Barran, P., Benesch, J. L. P., Bleiholder, C., Bowers, M. T., Bilbao, A., Bush, M. F., Campbell, J. L., et al. (2019) · Mass Spectrometry Reviews · doi:10.1002/mas.21585 · Cited by 493
Self-citationIon mobility mass spectrometry of proteins and proteinassemblies
Uetrecht, C., Rose, R. J., van Duijn, E., Lorenzen, K., & Heck, A. J. R. (2010) · Chem. Soc. Rev. · doi:10.1039/b914002f · Cited by 462
Breuker, K., & McLafferty, F. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807005105 · Cited by 423
Meier, F., Beck, S., Grassl, N., Lubeck, M., Park, M. A., Raether, O., & Mann, M. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00932 · Cited by 423
Norwalk Virus Assembly and Stability Monitored by Mass Spectrometry
Shoemaker, G. K., van Duijn, E., Crawford, S. E., Uetrecht, C., Baclayon, M., Roos, W. H., Wuite, G. J. L., Estes, M. K., Prasad, B. V. V., & Heck, A. J. R. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900620-mcp200 · Cited by 140
Metadata
- Authors
- Hoaglund, C. S., Valentine, S. J., Sporleder, C. R., Reilly, J. P., & Clemmer, D. E.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1998-05-05
- Volume
- 70
- Issue
- 11
- Pages
- 2236-2242
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2063715632
- Cited by
- 345
- References
- 1
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- closed
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