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Amperometric Glucose Biosensor Based on Sol−Gel Organic−Inorganic Hybrid Material
Abstract
A new type of sol-gel organic-inorganic hybrid material was developed and used for the production of biosensors. This material is composed of silica sol and a grafting copolymer of poly(vinyl alcohol) with 4-vinylpyridine. It prevents the cracking of conventional sol-gel-derived glasses and eliminates the swelling of the hydrogel. The optimum composition of the hybrid material was first examined, and then glucose oxidase was immobilized in this matrix to demonstrate its application. The characteristics of the biosensor were studied by cyclic voltammetry and chronoamperometry. The biosensor exhibited a series of good properties: high sensitivity (600 nA mmol-1 L-1), short response time (11 s) and remarkable long-term stability in storage (at least 5 months). In addition, the characteristics of the second-generation biosensor with the use of tetrathiafulvalene as a mediator were discussed.
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Citations
Cited by
Hydrogel Based Sensors for Biomedical Applications: An Updated Review
Tavakoli, J., & Tang, Y. (2017) · Polymers · doi:10.3390/polym9080364 · Cited by 434
Zhang, S., Wang, N., Yu, H., Niu, Y., & Sun, C. (2005) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2004.12.002 · Cited by 317
Ionic liquids in enzymatic catalysis and biochemical methods of analysis: Capabilities and prospects
Muginova, S. V., Galimova, A. Z., Polyakov, A. E., & Shekhovtsova, T. N. (2010) · Journal of Analytical Chemistry · doi:10.1134/s1061934810040027 · Cited by 36
Metadata
- Authors
- Wang, B., Li, B., Deng, Q., & Dong, S.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1998-07-07
- Volume
- 70
- Issue
- 15
- Pages
- 3170-3174
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1997525295
- Cited by
- 299
- References
- 0
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Amperometric Glucose Biosensor Based on Sol−Gel Organic−Inorganic Hybrid Material. https://app.cochat.ai/papers/10.1021/ac980160h
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- Wang, B., Li, B., Deng, Q., & Dong, S. (1998). Amperometric Glucose Biosensor Based on Sol−Gel Organic−Inorganic Hybrid Material. Analytical Chemistry. https://doi.org/10.1021/ac980160h
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
