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Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min
Open accessAbstract
The outbreak of SARS-CoV-2 is posing serious global public health problems. Facing the emergence of this pandemic, we established a portable microfluidic immunoassay system for easy-to-use, sensitive, rapid (<15 min), multiple, and on-site detection of IgG/IgM/Antigen of SARS-CoV-2 simultaneously. This integrated method was successfully applied for detecting SARS-CoV-2 IgM and IgG antibodies in clinical human serum as well as SARS-CoV-2 antigen in pharyngeal swabs from 26 patients with COVID-19 infection and 28 uninfected people. The assay demonstrated high sensitivity and specificity, which is promising for the diagnosis and monitoring as well as control of SARS-CoV-2 worldwide.
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Hui, D. S., I Azhar, E., Madani, T. A., Ntoumi, F., Kock, R., Dar, O., Ippolito, G., Mchugh, T. D., Memish, Z. A., Drosten, C., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.01.009 · Cited by 3,809
CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV)
Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., Cui, J., Xu, W., Yang, Y., Fayad, Z. A., et al. (2020) · Radiology · doi:10.1148/radiol.2020200230 · Cited by 2,751
Cited by
Recent Advances in Microfluidic Technology for Bioanalysis and Diagnostics
Berlanda, S. F., Breitfeld, M., Dietsche, C. L., & Dittrich, P. S. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04366 · Cited by 305
Yang, S.-M., Lv, S., Zhang, W., & Cui, Y. (2022) · Sensors · doi:10.3390/s22041620 · Cited by 299
Emerging Telemedicine Tools for Remote COVID-19 Diagnosis, Monitoring, and Management
Lukas, H., Xu, C., Yu, Y., & Gao, W. (2020) · ACS Nano · doi:10.1021/acsnano.0c08494 · Cited by 265
Metadata
- Authors
- Lin, Q., Wen, D., Wu, J., Liu, L., Wu, W., Fang, X., & Kong, J.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-07-02
- Volume
- 92
- Issue
- 14
- Pages
- 9454-9458
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W3039435774
- Cited by
- 203
- References
- 2
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lin, Q., Wen, D., Wu, J., Liu, L., Wu, W., Fang, X., & Kong, J. (2020). Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.0c01635
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
