The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dual-Signal Readout Nanospheres for Rapid Point-of-Care Detection of Ebola Virus Glycoprotein
Abstract
Rapid detection of highly contagious pathogens is the key to increasing the probability of survival and reducing infection rates. We developed a sensitive and quantitative lateral flow assay for detection of Ebola virus (EBOV) glycoprotein with a novel multifunctional nanosphere (RNs@Au) as a reporter. Each RNs@Au contains hundreds of quantum dots and dozens of Au nanoparticles and can achieve enhanced dual-signal readout (fluorescence signal for quantitative detection and colorimetric signal for visual detection). Antibody (Ab) and streptavidin (SA) were simultaneously modified onto the RNs@Au to label the target and act as signal enhancer. After the target was labeled by the Ab-RNs@Au-SA and captured on the test line, biotin-modified RNs@Au was used to amplify the dual signal by the reaction of SA with biotin. The assay enables naked-eye detection of 2 ng/mL glycoprotein within 20 min, and the quantitative detection limit is 0.18 ng/mL. Additionally, the assay has been successfully tested in field work for detecting EBOV in spiked urine, plasma, and tap water samples and is thus a promising candidate for early diagnosis of suspect infections in EBOV-stricken areas.
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Citations
Cites
Ebola virus disease in West Africa—the first 9 months of the epidemic and forward projections
WHO Ebola Response Team (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1411100 · Cited by 1,674
Cited by
Point-of-care diagnostics for infectious diseases: From methods to devices
Wang, C., Liu, M., Wang, Z., Li, S., Deng, Y., & He, N. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101092 · Cited by 622
Jain, S., Nehra, M., Kumar, R., Dilbaghi, N., Hu, T., Kumar, S., Kaushik, A., & Li, C.-Z. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113074 · Cited by 357
Magnetic SERS Strip for Sensitive and Simultaneous Detection of Respiratory Viruses
Wang, C., Wang, C., Wang, X., Wang, K., Zhu, Y., Rong, Z., Wang, W., Xiao, R., & Wang, S. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b03920 · Cited by 304
Liu, H., Dai, E., Xiao, R., Zhou, Z., Zhang, M., Bai, Z., Shao, Y., Qi, K., Tu, J., Wang, C., et al. (2021) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2020.129196 · Cited by 267
Metadata
- Authors
- Hu, J., Jiang, Y.-Z., Wu, L.-L., Wu, Z., Bi, Y., Wong, G., Qiu, X., Chen, J., Pang, D.-W., & Zhang, Z.-L.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-12-01
- Volume
- 89
- Issue
- 24
- Pages
- 13105-13111
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2769209484
- Cited by
- 159
- References
- 1
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hu, J., Jiang, Y.-Z., Wu, L.-L., Wu, Z., Bi, Y., Wong, G., Qiu, X., Chen, J., Pang, D.-W., & Zhang, Z.-L. (2017). Dual-Signal Readout Nanospheres for Rapid Point-of-Care Detection of Ebola Virus Glycoprotein. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.7b02222
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