Structural and Functional Influence of the Glycine-Rich Loop G 302 GGGY on the Catalytic Tyrosine of Histone Deacetylase 8

Porter, Nicholas J.; Christianson, Nicolas H.; Decroos, Christophe; Christianson, David W.

doi:10.1021/acs.biochem.6b01014

Structural and Functional Influence of the Glycine-Rich Loop G 302 GGGY on the Catalytic Tyrosine of Histone Deacetylase 8

Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-L-lysine to yield products L-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn2+ or Fe2+). Acetyl-L-lysine also requires activation b…