Recent Progress of Highly Adhesive Hydrogels as Wound Dressings
Abstract
Wound dressings are widely used to promote wound healing. Traditional dressings need the help of tape to fix onto the wounds, which are not suitable in the human body. In addition, hemostasis of internal wounds is usually treated with direct sutures which will cause secondary trauma to the patient and increase the risk of infection. Therefore, development of new dressings with high tissue adhesion and biocompatibility is of great clinical significance. The highly adhesive wound dressings can firmly attach to external and internal wounds, and form a barrier to prevent bacterial invasion, accelerate healing, and avoid secondary damage caused by sutures. Hydrogels are soft materials that possess a 3D network structure with tunable physical and chemical properties, which provides ideal conditions to support the wound healing process. In this review, we summarize the recent advances in developing hydrogel-based wound dressings as well as their adhesion mechanism. Moreover, the prospects of these wound dressings over the coming years are also covered.
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By incorporating PDA into hydrogel networks, multifunctional oral mucosal dressings with enhanced performance can be fabricated.
“By incorporating PDA into hydrogel networks, multifunctional oral mucosal dressings with enhanced performance can be fabricated.51”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [51]
Through this redox-regulating mechanism, PDA-based systems can effectively protect periodontal tissues from oxidative injury and contribute to inflammation resolution.
“Through this redox-regulating mechanism, PDA-based systems can effectively protect periodontal tissues from oxidative injury and contribute to inflammation resolution.12,51”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [51]
PDA-based nanoparticles or hydrogels are capable of adsorbing and neutralizing excess ROS, thereby directly exerting antioxidant and anti-inflammatory effects.
“PDA-based nanoparticles or hydrogels are capable of adsorbing and neutralizing these excess ROS, thereby directly exerting antioxidant and anti-inflammatory effects.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [51]
PDA functions as an efficient scavenger of reactive oxygen species (ROS).
“As discussed above, PDA functions as an efficient scavenger of reactive oxygen species (ROS).”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [51]
Cites
Adaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement
Maier, G. P., Rapp, M. V., Waite, J. H., Israelachvili, J. N., & Butler, A. (2015) · Science · doi:10.1126/science.aab0556 · Cited by 722 · see citing works
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Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
“51 The catechol moieties of PDA impart strong wet-tissue adhesive properties to the hydrogel, allowing stable attachment to irregular and saliva-covered mucosal wounds, resistance to mechanical displacement, and the formation of a durable physical barrier.”
- Authors
- Zhang, L., Liu, M., Zhang, Y., & Pei, R.
- Affiliations
- University of Science and Technology of China (CN)
- Jianghan University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Pei, Renjun
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-09-22
- Volume
- 21
- Issue
- 10
- Pages
- 3966-3983
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W3087008150
- Cited by
- 255
- References
- 1
- Citations by year
- 2026: 34 · 2025: 56 · 2024: 47 · 2023: 54 · 2022: 46 · 2021: 17 · 2020: 1
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BE2018665, BK20180256, BK20180258)
- National Natural Science Foundation of China (31971326)
- Chinese Academy of Sciences (XDA16040700)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- wound dressings, hydrogels, tissue adhesion, wound healing, adhesion mechanism, biocompatibility, bacterial infection prevention, suture alternatives
- MeSH terms
- Tissue Adhesions, Adhesives, Bandages, Humans, Wound Healing, Hydrogels
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