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Self-Healing Supramolecular Self-Assembled Hydrogels Based on Poly(l-glutamic acid)

Li, Guifei, Wu, Jie, Wang, Bo, Yan, Shifeng, Zhang, Kunxi, Ding, Jianxun, Yin, Jingbo·2015·Biomacromolecules

Abstract

Self-healing polymeric hydrogels have the capability to recover their structures and functionalities upon injury, which are extremely attractive in emerging biomedical applications. This research reports a new kind of self-healing polypeptide hydrogels based on self-assembly between cholesterol (Chol)-modified triblock poly(L-glutamic acid)-block-poly(ethylene glycol)-block-poly(L-glutamic acid) ((PLGA-b-PEG-b-PLGA)-g-Chol) and β-cyclodextrin (β-CD)-modified poly(L-glutamic acid) (PLGA-g-β-CD). The hydrogel formation relied on the host and guest linkage between β-CD and Chol. This study demonstrates the influences of polymer concentration and β-CD/Chol molar ratio on viscoelastic behavior of the hydrogels. The results showed that storage modulus was highest at polymer concentration of 15% w/v and β-CD/Chol molar ratio of 1:1. The effect of the PLGA molecular weight in (PLGA-b-PEG-b-PLGA)-g-Chol on viscoelastic behavior, mechanical properties and in vitro degradation of the supramolecular hydrogels was also studied. The hydrogels showed outstanding self-healing capability and good cytocompatibility. The multilayer structure was constructed using hydrogels with self-healing ability. The developed hydrogels provide a fascinating glimpse for the applications in tissue engineering.

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Metadata

Authors
Li, G., Wu, J., Wang, B., Yan, S., Zhang, K., Ding, J., & Yin, J.
Venue
Biomacromolecules
Published
2015-10-08
Volume
16
Issue
11
Pages
3508-3518
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2202134662
Cited by
186
References
1
FWCI
8.39
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Self-Healing Supramolecular Self-Assembled Hydrogels Based on Poly(l-glutamic acid). https://app.cochat.ai/papers/10.1021/acs.biomac.5b01287
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Li, G., Wu, J., Wang, B., Yan, S., Zhang, K., Ding, J., & Yin, J. (2015). Self-Healing Supramolecular Self-Assembled Hydrogels Based on Poly(l-glutamic acid). Biomacromolecules. https://doi.org/10.1021/acs.biomac.5b01287

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