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Self-Healing Supramolecular Self-Assembled Hydrogels Based on Poly(l-glutamic acid)
Abstract
Self-healing polymeric hydrogels have the capability to recover their structures and functionalities upon injury, which are extremely attractive in emerging biomedical applications. This research reports a new kind of self-healing polypeptide hydrogels based on self-assembly between cholesterol (Chol)-modified triblock poly(L-glutamic acid)-block-poly(ethylene glycol)-block-poly(L-glutamic acid) ((PLGA-b-PEG-b-PLGA)-g-Chol) and β-cyclodextrin (β-CD)-modified poly(L-glutamic acid) (PLGA-g-β-CD). The hydrogel formation relied on the host and guest linkage between β-CD and Chol. This study demonstrates the influences of polymer concentration and β-CD/Chol molar ratio on viscoelastic behavior of the hydrogels. The results showed that storage modulus was highest at polymer concentration of 15% w/v and β-CD/Chol molar ratio of 1:1. The effect of the PLGA molecular weight in (PLGA-b-PEG-b-PLGA)-g-Chol on viscoelastic behavior, mechanical properties and in vitro degradation of the supramolecular hydrogels was also studied. The hydrogels showed outstanding self-healing capability and good cytocompatibility. The multilayer structure was constructed using hydrogels with self-healing ability. The developed hydrogels provide a fascinating glimpse for the applications in tissue engineering.
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Self-healing gels based on constitutional dynamic chemistry and their potential applications
Wei, Z., Yang, J. H., Zhou, J., Xu, F., Zrínyi, M., Dussault, P. H., Osada, Y., & Chen, Y. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00219a · Cited by 896
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Conducting Polymers for Tissue Engineering
Guo, B., & Ma, P. X. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00276 · Cited by 835
Shao, C., Wang, M., Meng, L., Chang, H., Wang, B., Xu, F., Yang, J., & Wan, P. (2018) · Chemistry of Materials · doi:10.1021/acs.chemmater.8b01172 · Cited by 783
Self-citationXia, D., Wang, P., Ji, X., Khashab, N. M., Sessler, J. L., & Huang, F. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00839 · Cited by 734
Xanthan gum derivatives: review of synthesis, properties and diverse applications
Patel, J., Maji, B., Moorthy, N. S. H. N., & Maiti, S. (2020) · RSC Advances · doi:10.1039/d0ra04366d · Cited by 336
Chen, M., Tian, J., Liu, Y., Cao, H., Li, R., Wang, J., Wu, J., & Zhang, Q. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.05.043 · Cited by 281
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Metadata
- Authors
- Li, G., Wu, J., Wang, B., Yan, S., Zhang, K., Ding, J., & Yin, J.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-10-08
- Volume
- 16
- Issue
- 11
- Pages
- 3508-3518
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2202134662
- Cited by
- 186
- References
- 1
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, G., Wu, J., Wang, B., Yan, S., Zhang, K., Ding, J., & Yin, J. (2015). Self-Healing Supramolecular Self-Assembled Hydrogels Based on Poly(l-glutamic acid). Biomacromolecules. https://doi.org/10.1021/acs.biomac.5b01287
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