The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Reduction of Substrates by Nitrogenases
Open accessAbstract
Nitrogenase is the enzyme that catalyzes biological N 2 reduction to NH 3 . This enzyme achieves an impressive rate enhancement over the uncatalyzed reaction. Given the high demand for N 2 fixation to support food and chemical production and the heavy reliance of the industrial Haber–Bosch nitrogen fixation reaction on fossil fuels, there is a strong need to elucidate how nitrogenase achieves this difficult reaction under benign conditions as a means of informing the design of next generation synthetic catalysts. This Review summarizes recent progress in addressing how nitrogenase catalyzes the reduction of an array of substrates. New insights into the mechanism of N 2 and proton reduction are first considered. This is followed by a summary of recent gains in understanding the reduction of a number of other nitrogenous compounds not considered to be physiological substrates. Progress in understanding the reduction of a wide range of C-based substrates, including CO and CO 2, is also discussed, and remaining challenges in understanding nitrogenase substrate reduction are considered.
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Cites
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Structural insights into the iron nitrogenase complex
Schmidt, F. V., Schulz, L., Zarzycki, J., Prinz, S., Oehlmann, N. N., Erb, T. J., & Rebelein, J. G. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01124-2 · Cited by 56
Architecture of the RNF1 complex that drives biological nitrogen fixation
Zhang, L., & Einsle, O. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01641-1 · Cited by 25
Barahona, E., Collantes-García, J. A., Rosa-Núñez, E., Xiong, J., Jiang, X., Jiménez-Vicente, E., Echávarri-Erasun, C., Guo, Y., Rubio, L. M., & González-Guerrero, M. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107900 · Cited by 7
Metadata
- Authors
- Seefeldt, L. C., Yang, Z.-Y., Lukoyanov, D. A., Harris, D. F., Dean, D. R., Raugei, S., & Hoffman, B. M.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-03-16
- Volume
- 120
- Issue
- 12
- Pages
- 5082-5106
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3011033957
- Cited by
- 396
- References
- 180
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Seefeldt, L. C., Yang, Z.-Y., Lukoyanov, D. A., Harris, D. F., Dean, D. R., Raugei, S., & Hoffman, B. M. (2020). Reduction of Substrates by Nitrogenases. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.9b00556
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
