Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson’s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder
Abstract
This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-synuclein (α-SYN) aggregates in the substantia nigra (SN) of Parkinson’s disease (PD) mice via 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced. Our results indicated that L. plantarum DP189 increased the levels of superoxide dismutase (SOD), glutathione peroxide (GSH-Px), and interleukin-10 (IL-10) and decreased the levels of malondialdehyde (MDA), reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). Moreover, L. plantarum DP189 reduced the α-SYN accumulation in SN. Mechanistically, L. plantarum DP189 activated the expression of nuclear factor erythroid 2-related factor (Nrf2)/ARE and PGC-1α pathways and suppressed the NLRP3 inflammasome. Furthermore, fecal analysis showed that L. plantarum DP189 reshaped the gut microbiota in PD mice by reducing the number of pathogenic bacteria ( Proteobacteria and Actinobacteria ) and increased the abundance of probiotics ( Lactobacillus and Prevotella ). Our results suggested that L. plantarum DP189 could delay the neurodegeneration caused by the accumulation of α-SYN in the SN of PD mice via suppressing oxidative stress, repressing proinflammatory response, and modulating gut microbiota.
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L. plantarum DP189 slows neurodegeneration via inhibition of oxidative stress, reduction of the proinflammatory response, and modification of the gut microbiota in mice.
“L. plantarum DP189 was found to slow neurodegeneration via inhibition of oxidative stress, reduction of the proinflammatory response, and modification of the gut microbiota in mice [71]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [71]
Intraperitoneal injection of MPTP can induce marked gut dysbacteriosis.
“intraperitoneal injection of MPTP can induce marked gut dysbacteriosis [33, 49, 71]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [71]
In clinical studies, probiotics lower the development of α-synuclein aggregates by lowering ROS levels, thereby improving the condition of patients with PD.
“In clinical studies, probiotics have been shown to lower the development of α-synuclein aggregates by lowering ROS levels, thereby improving the condition of patients with PD [37,39].”
From Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease (2022) · cites this paper as [39]
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References 55 · Cited by 203
- Authors
- Wang, L., Zhao, Z., Zhao, L., Zhao, Y., Yang, G., Wang, C., Gao, L., Niu, C., & Li, S.
- Affiliations
- Jilin Academy of Agricultural Sciences (CN)
- Changchun University of Chinese Medicine (CN)
- Corresponding author
- Li, Shengyu
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-01-24
- Volume
- 70
- Issue
- 4
- Pages
- 1163-1173
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W4207053585
- Cited by
- 203
- References
- 55
- Citations by year
- 2026: 39 · 2025: 62 · 2024: 58 · 2023: 26 · 2022: 18
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Agriculture Research System of MOF and MARA
- Jilin Province Science and Technology Development Plan (20210101424JC)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Parkinson's disease, alpha-synuclein aggregation, MPTP-induced neurotoxicity, substantia nigra, oxidative stress, neuroinflammation, gut microbiota, Nrf2/ARE pathway, NLRP3 inflammasome, probiotics, neuroprotection
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Models, Animal, Inflammation, Mice, Inbred C57BL, Parkinson Disease, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Oxidative Stress, Lactiplantibacillus plantarum, Mice, alpha-Synuclein
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