The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Using ChatGPT for Method Development and Green Chemistry Education in Upper-Level Laboratory Courses
Abstract
High Resolution Image Download MS PowerPoint Slide Large language models (LLMs) such as ChatGPT are being used for outlining, writing assistance, and higher-level research tasks in many areas of science. The purpose of the work described here was to assess ChatGPT version 3.5’s ability to help upper-level Analytical and Inorganic Chemistry students find methods and green modifications to use in laboratory proposals. Some students found that ChatGPT provided a helpful starting point, but it mostly gave vague and erroneous responses when asked to provide upper-level methods in these areas, particularly in green chemistry. Few ChatGPT suggestions were useful for students’ proposals. Students usually used reasonable prompts, and they often evaluated ChatGPT outputs correctly; however, most students reported they were not confident using its responses. Some lacked confidence in ChatGPT outputs because it rarely provided references, and some said they preferred formal literature searching. Despite ChatGPT’s deficiencies in producing usable methods, we found evidence that these were valuable exercises for helping students think critically about procedures and artificial intelligence (AI) outputs. An accompanying anonymous survey suggested that student opinions of ChatGPT and AI technologies varied depending on what they had used them for. Based on this work, we offer suggestions for other instructors who wish to design similar method development assignments that incorporate LLMs.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These findings, across domains including medical education (Cheng et al., 2025), health sciences (Jedrzejczak et al., 2024), and chemistry education (Ruff et al., 2024), suggest that DOI hallucination is systematic rather than incidental.”
From Geographic Variation in LLM DOI Fabrication: Cross-Country Analysis of Citation Accuracy Across Four Large Language Models (2025) · cites this paper as Ruff et al., 2024
Citations
Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Scientific discovery in the age of artificial intelligence.
Wang, H., Fu, T., Du, Y., Gao, W., Huang, K., Liu, Z., Chandak, P., Liu, S., Van Katwyk, P., Deac, A., et al. (2023) · Nature · doi:10.1038/s41586-023-06221-2 · Cited by 1,823
Autonomous chemical research with large language models
Boiko, D. A., MacKnight, R., Kline, B., & Gomes, G. (2023) · Nature · doi:10.1038/s41586-023-06792-0 · Cited by 1,050
Updating and further expanding GSK's solvent sustainability guide
Alder, C. M., Hayler, J. D., Henderson, R. K., Redman, A. M., Shukla, L., Shuster, L. E., & Sneddon, H. F. (2016) · Green Chemistry · doi:10.1039/c6gc00611f · Cited by 1,041
The impact of ChatGPT on higher education
Dempere, J., Modugu, K., Hesham, A., & Ramasamy, L. K. (2023) · Frontiers in Education · doi:10.3389/feduc.2023.1206936 · Cited by 519
Generative AI in Education and Research: Opportunities, Concerns, and Solutions
Alasadi, E. A., & Baiz, C. R. (2023) · Journal of Chemical Education · doi:10.1021/acs.jchemed.3c00323 · Cited by 463
Evaluating Academic Answers Generated Using ChatGPT
Fergus, S., Botha, M., & Ostovar, M. (2023) · Journal of Chemical Education · doi:10.1021/acs.jchemed.3c00087 · Cited by 300
Leveraging ChatGPT for Enhancing Critical Thinking Skills
Guo, Y., & Lee, D. (2023) · Journal of Chemical Education · doi:10.1021/acs.jchemed.3c00505 · Cited by 250
ChatGPT Research Group for Optimizing the Crystallinity of MOFs and COFs
Zheng, Z., Zhang, O., Nguyen, H. L., Rampal, N., Alawadhi, A. H., Rong, Z., Head-Gordon, T., Borgs, C., Chayes, J. T., & Yaghi, O. M. (2023) · ACS Central Science · doi:10.1021/acscentsci.3c01087 · Cited by 172
Exintaris, B., Karunaratne, N., & Yuriev, E. (2023) · Journal of Chemical Education · doi:10.1021/acs.jchemed.3c00481 · Cited by 123
West, J. K., Franz, J. L., Hein, S. M., Leverentz-Culp, H. R., Mauser, J. F., Ruff, E. F., & Zemke, J. M. (2023) · Journal of Chemical Education · doi:10.1021/acs.jchemed.3c00581 · Cited by 79
Self-citationEmergent autonomous scientific research capabilities of large language models
Boiko, D. A., MacKnight, R., & Gomes, G. (2023) · arXiv · doi:10.48550/arxiv.2304.05332 · Cited by 72
Designing Chemical Reaction Arrays Using Phactor and ChatGPT
Mahjour, B., Hoffstadt, J., & Cernak, T. (2023) · Organic Process Research & Development · doi:10.1021/acs.oprd.3c00186 · Cited by 41
Research works printed but not linked: 56
- ACS Approval Program ; American Chemical Society, 2024. https://www.acs.org/education/policies/acs-approval-program.html (accessed 02-08-2024).
- 10.1021/acs.jchemed.1c00817 · DOI
- 10.1021/acs.jchemed.3c00547 · DOI
- 10.1021/ed079p524 · DOI
- Smith T. L., 2017, Chem. Educ., 22, 177
- 10.1021/acs.jchemed.7b00093 · DOI
- 10.1021/acs.jchemed.0c01140 · DOI
- 10.1021/ed400130s · DOI
- 10.1021/acs.jchemed.5b00160 · DOI
- 10.1021/ed1011103 · DOI
- 10.1021/ed400595j · DOI
- 10.1021/acs.jchemed.5b00854 · DOI
- 10.1021/acs.jchemed.8b00102 · DOI
- 10.1021/ed082p1794 · DOI
- 10.1007/s00897990314a · DOI
- 10.1021/ed073p1026 · DOI
- 10.1021/ed5007019 · DOI
- 10.1021/acs.jchemed.0c01251 · DOI
- 10.1021/acs.jchemed.1c00035 · DOI
- 10.1021/acs.jchemed.2c00113 · DOI
- 10.1021/acs.jchemed.8b00826 · DOI
- 10.1021/acs.jchemed.1c00843 · DOI
- 10.1021/ed085p1519 · DOI
- 10.1021/ed200756z · DOI
- 10.1021/ed300468r · DOI
- Novak M., 2007, Chem. Educ., 12, 414
- 10.1007/s00897000453a · DOI
- 10.1021/acs.jchemed.5b00678 · DOI
- Anderson L. W., 2001, A Taxonomy for Learning, Teaching, and Assessing: A Revision of Bloom’s Taxonomy of Educational Objectives, Complete
- Anastas P. T., 1998, Green Chemistry: Theory and Practice
- 12 Principles of Green Chemistry ; American Chemical Society, 2024. https://www.acs.org/greenchemistry/principles/12-principles-of-green-chemistry.html (accessed 02-13-2024).
- 10.1021/acs.jchemed.4c00161 · DOI
- 10.1021/acs.jchemed.1c00947 · DOI
- 10.1016/j.caeai.2023.100170 · DOI
- 10.1021/acs.jchemed.3c00006 · DOI
- 10.1021/acs.jchemed.3c00063 · DOI
- 10.1039/D3RP00088E · DOI
- 10.1021/acs.jchemed.3c00361 · DOI
- 10.1021/acs.jchemed.3c00027 · DOI
- 10.1021/acs.jchemed.3c00288 · DOI
- 10.1021/acs.jcim.1c00619 · DOI
- 10.3390/life12091430 · DOI
- 10.1021/jacs.3c05819 · DOI
- 10.26434/chemrxiv-2023-3zcfl-v3 · DOI
- 10.1038/s41592-023-02087-4 · DOI · Paper page
- 10.1126/science.adm9788 · DOI
- 2023, ACS Axial
- Mullin, R. The tricky ethics of AI in the lab. Chemical & Engineering News ; American Chemical Society, 2023. https://cen.acs.org/business/informatics/tricky-ethics-AI-lab/101/i31 (accessed 09-26-2023).
- 10.1021/acs.jchemed.4c00248 · DOI
- 10.1021/cr068359e · DOI
- 10.1016/S0731-7085(01)00661-6 · DOI
- 10.1021/jf070413k · DOI
- 10.1098/rsos.191378 · DOI
- 10.1007/s11251-021-09559-0 · DOI
- 10.1016/j.learninstruc.2007.09.008 · DOI
- 10.1038/s41598-024-52549-8 · DOI
Cited by
Yuriev, E., Burton, M. G., Knott, D., Terrill, A. E., Jackson, N. R. C., & Chen, S. (2025) · Journal of Chemical Education · doi:10.1021/acs.jchemed.4c01499 · Cited by 26
Kim, E., Kipchumba, F., & Min, S. (2025) · Publications · doi:10.3390/publications13040049 · Cited by 7
Metadata
- Authors
- Ruff, E. F., Franz, J. L., & West, J. K.
- Affiliations
- Department of Chemistry, Winona State University, 175 W Mark St., Winona, Minnesota 55987, United States
- Venue
- Journal of Chemical Education
- Publisher
- American Chemical Society (ACS)
- Published
- 2024-07-23
- Volume
- 101
- Issue
- 8
- Pages
- 3224-3232
- ISSN
- 0021-9584
- 1938-1328
- Cited by
- 40
- References
- 13
- Language
- en
- Funders
- Winona State University
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.