The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
The Most Common Functional Groups in Bioactive Molecules and How Their Popularity Has Evolved over Time
Abstract
The concept of functional groups (FGs), sets of connected atoms that can determine the intrinsic reactivity of the parent molecule and in part are responsible for the overall properties of the molecule, form a foundation within modern medicinal chemistry. In this Article, we analyze the occurrence of various FGs in molecules described in the medicinal chemistry literature over the last 40 years and show how their development and utilization over time has varied. The popularity of various FGs has not evolved randomly, but instead, clear patterns of use are evident. Various factors influencing these patterns, including the introduction of new synthetic methods, novel techniques, and strategies applied in drug discovery and the better knowledge of molecular properties affecting the success of candidate development, are discussed.
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ZINC 15 – Ligand Discovery for Everyone
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ChEMBL: towards direct deposition of bioassay data
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Cited by
Masui, H., & Fuse, S. (2022) · Organic Process Research & Development · doi:10.1021/acs.oprd.2c00074 · Cited by 38
Metadata
- Authors
- Ertl, P., Altmann, E., & McKenna, J. M.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-07-14
- Volume
- 63
- Issue
- 15
- Pages
- 8408-8418
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W3042595256
- Cited by
- 429
- References
- 70
- FWCI
- 18.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ertl, P., Altmann, E., & McKenna, J. M. (2020). The Most Common Functional Groups in Bioactive Molecules and How Their Popularity Has Evolved over Time. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.0c00754
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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