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New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

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Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives

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Diffusion Limit and the Reactivity/Affinity Conundrum: Implications for Optimization and Hit Finding for Irreversible Modulators

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Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

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Anticancer potential of novel α,β-unsaturated γ-lactam derivatives targeting the PI3K/AKT signaling pathway

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pH adjustment improves the removal of disinfection byproduct precursors from sedimentation sludge water

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Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A

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Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer

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Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH

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Sesquiterpenoids from Artemisia argyi and their NO production inhibitory activity in RAW264.7 cells

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Primaquine derivatives: Modifications of the terminal amino group

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DNA unchained: two assays to discover and study inhibitors of the DNA clustering function of barrier-to-autointegration factor

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Enantioselective assembly of 3,3-disubstituted succinimides via three-component reaction of vinyl diazosuccinimides with alcohols and imines

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Asymmetric Synthesis of α‐Methylene‐γ‐Butyrolactones via Tandem Allylboration/Lactonization: a Kinetic Resolution Process

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Scaffold Hopping of α,β-Unsaturated Ketones via Divergent Alkyl Amine Insertion

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Conceptual density functional theory in drug discovery: an overview

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Design, synthesis, and anticancer evaluation of novel andrographolide derivatives bearing an α,β-unsaturated ketone moiety

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Imidazolone as an Amide Bioisostere in the Development of β-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors

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Ten-Step Total Synthesis of (±)-Phaeocaulisin A Enabled by Cyclopropanol Ring-Opening Carbonylation

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Recent advancements in colchicine derivatives: Exploring synthesis, activities, and nanoformulations for enhanced therapeutic efficacy

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Palladium‐Catalyzed Carbonylation in the Synthesis of N‐Ynonylsulfoximines

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Convenient preparation of (E)-3-arylidene-4-diazopyrrolidine-2,5-diones in array format

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Protein Modifications: From Chemoselective Probes to Novel Biocatalysts

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Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease

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Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice

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Catalytic asymmetric defluorinative allylation of silyl enol ethers

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Quantitation of Lipid Peroxidation Product DNA Adducts in Human Prostate by Tandem Mass Spectrometry: A Method That Mitigates Artifacts

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Improving predictive capacity of the Amino acid Derivative Reactivity Assay test method for skin sensitization potential with an optimal molar concentration of test chemical solution

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Selectively triggered: ROS-activated Michael acceptor prodrug strategy to enhance tumor targeting efficacy

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Citral: A Plant-Derived Compound with Excellent Potential for Sustainable Crop Protection

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Efficient identification of novel anti-glioma lead compounds by machine learning models

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Green electrosynthesis of drug metabolites

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Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy

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A Photochemical Strategy towards Michael Addition Reactions of Cyclopropenes

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Warheads for designing covalent inhibitors and chemical probes

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Inhibition of Pro‐Inflammatory Functions of Human Neutrophils by Constituents of Melodorum fruticosum Leaves

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Iridium-Catalyzed Oxidant-Free Transfer Dehydrogenation of Carboxylic Acids

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Total synthesis and target identification of marine cyclopiane diterpenes

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Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana

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Development of ion pairing LC-MS/MS method for itaconate and cis-aconitate in cell extract and cell media

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Thiol-trapping natural products under the lens of the cysteamine assay: friends, foes, or simply alternatively reversible ligands?

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Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate

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Computer-Aided Discovery and Redesign for Respiratory Sensitization: A Tiered Mechanistic Model to Deliver Robust Performance Across a Diverse Chemical Space

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Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability

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Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk)

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Multilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism

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In Vitro Antibacterial, Antifungal Activities, Reactivity, Bioactivity, GUSAR, Cytotoxicity Profiles, Molecular Docking, and Dynamic Simulations of Quinoline Acrylonitrile Derivatives

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How to nurture natural products to create new therapeutics: Strategic innovations and molecule-to-medicinal insights into therapeutic advancements

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Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling

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Total Synthesis of Stelletins through an Unconventional Annulation Strategy

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New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer

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A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells

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Untargeted metabolomics screening reveals unique secondary metabolite production from Alternaria section Alternaria

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Machine learning-based classification models for non-covalent Bruton’s tyrosine kinase inhibitors: predictive ability and interpretability

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Fibroblast growth factor receptor inhibitors: patent review (2015–2019)

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Characterization of covalent protein modification by triclosan in vivo and in vitro via three-dimensional liquid chromatography-mass spectrometry: New insight into its adverse effects

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Isolation of a natural product with anti-mitotic activity from a toxic Canadian prairie plant

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Design of ROS-Triggered Sesquiterpene Lactone SC Prodrugs as TrxR1 Covalent Inhibitors for the Treatment of Non-Small Cell Lung Cancer

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Mechanistic insights into citral-induced cellular damage and its antibacterial efficacy against Listeria monocytogenes

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Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles

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Studies of Cytotoxicity Effects, SARS‐CoV‐2 Main Protease Inhibition, and in Silico Interactions of Synthetic Chalcones

Fernandes, O. L. G., Tizziani, T., Dambrós, B. P., de Sousa, N. F., Pontes, C. L. M., da Silva, L. A. L., Pollo, L. A. E., de Assis, F. F., Scotti, L., Scotti, L., et al. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201151 · Cited by 12

Optimizing rheological performance of unsaturated polyester resin with bio-based reactive diluents: A comprehensive analysis of viscosity and thermomechanical properties

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Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target

Woo, J.-H., Park, J., Jang, J., Yang, H., Surh, Y., & Na, H. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108469 · Cited by 12

Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin

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Discovery of novel dihydroartemisinin-cinnamic hybrids inducing lung cancer cells apoptosis via inhibition of Akt/Bad signal pathway

Hu, Y., Wang, Y., Li, N., Chen, L., & Sun, J. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104903 · Cited by 12

Water‐Assisted and Catalyst‐Free Hetero‐Michael Additions: Mechanistic Insights from DFT Investigations

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Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

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Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells

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Generation of Leads for γ‑Secretase Modulation

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Antitrypanosomal Lactones from Nectandra barbellata

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High‐Throughput Experimentation and Machine Learning‐Assisted Optimization of Iridium‐Catalyzed Cross‐Dimerization of Sulfoxonium Ylides

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Exploring the Therapeutic Potential of Chalcones in Oncology: A Comprehensive Review

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β-Silyl alkynoates: Versatile reagents for biocompatible and selective amide bond formation

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Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold

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Selective Synthesis of Z -Michael Acceptors via Hydroalkylation of Conjugated Alkynes

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β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins

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