The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
Open accessAbstract
We have previously reported on classes of compounds that can interfere with bioassays via a number of different mechanisms and termed such compounds Pan Assay INterference compoundS, or PAINS. These compounds were defined on the basis of high-throughput data derived from vendor-supplied synthetics. The question therefore arises whether the concept of PAINS is relevant to compounds of natural origin. Here, it is shown that this is indeed the case, but that the context of the biological readout is an important factor that must be brought into consideration.
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Cites
Natural products as sources of new drugs over the 30 years from 1981 to 2010
Newman, D. J., & Cragg, G. M. (2012) · Journal of Natural Products · doi:10.1021/np200906s · Cited by 4,687
The promise and peril of chemical probes
Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1867 · Cited by 839
Self-citationGroll, M., Kim, K. B., Kairies, N., Huber, R., & Crews, C. M. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993588m · Cited by 304
Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK
Pennington, M., Chang, S., Chauhan, S., Huq, R., Tajhya, R., Chhabra, S., Norton, R., & Beeton, C. (2015) · Marine Drugs · doi:10.3390/md13010529 · Cited by 70
Cited by
The Essential Medicinal Chemistry of Curcumin
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Poly(2-oxazoline)s based biomaterials: a comprehensive and critical update
Lorson, T., Lübtow, M. M., Wegener, E., Haider, M. S., Borova, S., Nahm, D., Jordan, R., Sokolski-Papkov, M., Kabanov, A. V., & Luxenhofer, R. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.022 · Cited by 391
Natural Products as a Source for Novel Antibiotics
Moloney, M. G. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.001 · Cited by 308
Lübtow, M. M., Hahn, L., Haider, M. S., & Luxenhofer, R. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b05376 · Cited by 120
Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents
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Metadata
- Authors
- Baell, J. B.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-02-22
- Volume
- 79
- Issue
- 3
- Pages
- 616-628
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2327974216
- Cited by
- 539
- References
- 4
- FWCI
- 46.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Baell, J. B. (2016). Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS). Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.5b00947
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