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Enzyme-Powered Hollow Mesoporous Janus Nanomotors
Open accessAbstract
The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-propulsion. Here, we fabricate self-propelled Janus nanomotors based on hollow mesoporous silica nanoparticles (HMSNPs), which are powered by biocatalytic reactions of three different enzymes: catalase, urease, and glucose oxidase (GOx). The active motion is characterized by a mean-square displacement (MSD) analysis of optical video recordings and confirmed by dynamic light scattering (DLS) measurements. We found that the apparent diffusion coefficient was enhanced by up to 83%. In addition, using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications.
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Cited by
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Fuel‐Free Synthetic Micro‐/Nanomachines
Xu, T., Gao, W., Xu, L., Zhang, X., & Wang, S. (2017) · Advanced Materials · doi:10.1002/adma.201603250 · Cited by 417
Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors
Hortelão, A. C., Carrascosa, R., Murillo-Cremaes, N., Patiño, T., & Sánchez, S. (2019) · ACS Nano · doi:10.1021/acsnano.8b06610 · Cited by 287
Self-citationUltrasound-activated ciliary bands for microrobotic systems inspired by starfish
Dillinger, C., Nama, N., & Ahmed, D. (2021) · Nature Communications · doi:10.1038/s41467-021-26607-y · Cited by 149
Metadata
- Authors
- Ma, X., Jannasch, A., Albrecht, U.-R., Hahn, K., Miguel-López, A., Schäffer, E., & Sánchez, S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-10-05
- Volume
- 15
- Issue
- 10
- Pages
- 7043-7050
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2412956603
- Cited by
- 514
- References
- 0
- FWCI
- 22.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ma, X., Jannasch, A., Albrecht, U.-R., Hahn, K., Miguel-López, A., Schäffer, E., & Sánchez, S. (2015). Enzyme-Powered Hollow Mesoporous Janus Nanomotors. Nano Letters. https://doi.org/10.1021/acs.nanolett.5b03100
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