Silk Acid-Mediated Phase Separation of PEDOT:PSS for Biocompatible, Flexible Neural Interfaces
Abstract
Flexible multielectrode arrays (MEAs) are pivotal for elucidating the complex mechanisms of neural information transfer. A key challenge lies in developing ultrathin, highly compliant electrodes with high conductivity, low impedance, and excellent biocompatibility to establish conformal contact with organ surfaces. This enables precise recording of electrophysiological signal propagation with high spatiotemporal resolution, critical for deciphering physiological function. Conventional organic substrates, often thicker and possessing a higher Young’s modulus, typically lack the necessary stretchability and conformability for dynamic interfaces. To overcome this, gold electrodes were modified by spin-coating a composite conductive layer of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) doped with silk acid (SA) onto an ultrathin parylene substrate. Impedance of these flexible MEAs decreased with SA doping, indicating enhanced electrical conductivity. Furthermore, SA incorporation mitigated the intrinsic cytotoxicity of PEDOT:PSS. This optimized electrode design enables epileptic signal recording with a high signal-to-noise ratio (SNR) in the rat somatosensory cortex.
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- Authors
- Liang, K., Xia, T., Zhang, F., Jin, R., Ren, S., Xing, L., Wang, S., Dong, S., Zhang, S., Guo, C., & Zhu, B.
- Affiliations
- Zhejiang University (CN)
- Westlake University (CN)
- Westlake Institute for Optoelectronics , , ,
- Corresponding author
- Liang, Kun
- Guo, Chengchen
- Zhu, Bowen
- Venue
- ACS Applied Bio Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2026-09-24
- Volume
- 9
- Issue
- 19
- Pages
- 9135-9143
- ISSN
- 2576-6422 (ISSN-L)
- OpenAlex
- W7214201427
- Cited by
- 0
- References
- 50
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Bio Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Key Project of Westlake Institute for Optoelectronics (2023GD004)
- National Basic Research Program of China (973 Program) (2024YFA1208800)
- National Natural Science Foundation of China (NSFC) (62504208, 62574169, 92464105)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Keywords
- PEDOT:PSS, phase separation, flexible neural interfaces, microelectrode arrays, parylene substrate, gold electrode, biocompatibility, electrical conductivity, impedance, cytotoxicity, stretchable electrodes
- MeSH terms
- Phase Separation, Animals, Biocompatible Materials, Electric Conductivity, Electrodes, Materials Testing, Particle Size, Polymers, Polystyrenes, Surface Properties, Thiophenes, Bridged Bicyclo Compounds, Heterocyclic, Silk, Rats
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