Carboxymethyl Cellulose, Pluronic, and Pullulan-Based Compositions Efficiently Enhance Antiadhesion and Tissue Regeneration Properties without Using Any Drug Molecules
Abstract
Pharmacological-based treatment approaches have been used over time to prevent postlaparotomy adhesion. However, the rapid elimination of therapeutics from the peritoneum, and their unwanted side effects, easy flow from the wound site by gravity, and low therapeutic efficacy increase the urgent need for the next generation of antiadhesion agents. This article represents the development of biocompatible and biodegradable antiadhesion agents that consist of carboxymethyl cellulose (CMC) and pullulan with three different types of physical characteristics such as the solution type (ST), film type (FT), and thermosensitive type (TST). These antiadhesion agents that contain no drugs exhibit excellent physical characteristics and superior stability over 30 days in the operative sites without any toxicity and side effects that make the compositions strong candidates as novel antiadhesion agents. Also, the proposed samples reveal superior antiadhesion and tissue regeneration properties in Sprague-Dawley (SD) rats after surgery over Medicurtain. Medicurtain effectively prevented postlaparotomy adhesion in ∼42% of experimental animals, whereas ST 2.25-10, ST 2.5-5, ST 2.5-10, FT 20, and TST 1.5 were effective in 100% of animals. Thus, we believe these antiadhesion agents could be promising to reduce adhesion-related complications during and post-surgical operations and deserve consideration for further study for clinical purposes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Medicurtain prevented postoperative adhesions in approximately 42% of animals, whereas new CMC-pullulan formulations prevented adhesions in 100% of treated rats.
“Medicurtain prevented postoperative adhesions in ~42% of animals, whereas the new CMC–pullulan formulations prevented adhesions in 100% of the treated rats.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [142]
The CMC-pullulan study noted enhanced tissue regeneration at the surgical site, suggesting the materials might actively support healing.
“The study also noted enhanced tissue regeneration at the surgical site with these formulations, suggesting that the materials might actively support healing [142].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [142]
CMC-pullulan composite barriers are biodegradable over approximately 30 days and were designed to promote tissue healing while blocking adhesions.
“These materials are biodegradable over ~30 days and were designed to promote tissue healing while blocking adhesions.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [142]
In a rat laparotomy model, CMC-pullulan barriers showed excellent biocompatibility (no toxicity or inflammation) and impressive efficacy.
“In a rat laparotomy model, the CMC–pullulan barriers showed excellent biocompatibility (no toxicity or inflammation) and impressive efficacy.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [142]
All rats treated with optimized CMC-pullulan barriers had a completely adhesion-free recovery, a dramatic improvement over the control agent.
“In other words, all rats treated with optimized CMC–pullulan barriers had a completely adhesion-free recovery, a dramatic improvement over the control agent.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [142]
Cited by
Sorted by citations
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- An, J. M., Shahriar, S. M. S., Hasan, M. N., Cho, S., & Lee, Y.-K.
- Affiliations
- Korea National University of Transportation (KR)
- Corresponding author
- Lee, Yong-kyu
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-04-02
- Volume
- 13
- Issue
- 14
- Pages
- 15992-16006
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W3152220420
- Cited by
- 40
- References
- 0
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 11 · 2022: 10 · 2021: 3
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2018R1D1A1A09083269, 2019R1A4A1024116)
- Topics
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Keywords
- carboxymethyl cellulose, pullulan, poloxamer, biodegradable polymers, tissue regeneration, thermosensitive hydrogel, peritoneal adhesions
- MeSH terms
- Tissue Adhesions, Animals, Carboxymethylcellulose Sodium, Female, Glucans, Postoperative Complications, Regeneration, Rats, Sprague-Dawley, Poloxamer, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
