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Efficient Synthesis of Hydrophilic Hairy Semihollow Molecularly Imprinted Polymer Microcapsules with Ultrahigh Drug Loading and pH-Responsive Sustained Release Properties

Zhou, Yan, Mu, Yanyan, Zhang, Huiqi·2025·ACS Applied Materials & Interfaces
DOI 10.1021/acsami.5c19502
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Abstract

A highly efficient approach to obtaining well-defined hydrophilic hairy semihollow molecularly imprinted polymer (MIP) microcapsules with ultrahigh drug loading and pH-responsive sustained release properties is described, which involves grafting of a thin propranolol-MIP layer and poly(2-hydroxyethyl methacrylate) (PHEMA) brushes onto the "living" poly(methacrylic acid) (PMAA) microspheres (prepared by one-pot reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization) via two-step surface-initiated RAFT polymerization and rapid etching of part of the PMAA core from the resulting core-shell-corona-structured MIP particles by methanol washing. Both the MIP layer thickness and etching degrees of the obtained core-shell-structured MIP particles could be easily tuned by adjusting the polymerization time, and the surface-grafting of PHEMA brushes was well-controlled. The unique structure of the semihollow MIP microcapsules with PMAA chains inside cavities endowed them with ultrahigh template loading capacities (1637 and 1065 μmol/g for MIP microcapsules without and with PHEMA brushes, respectively, which are much higher than those of the previously reported propranolol-MIPs (from dozens to 600 μmol/g)). Additionally, they showed high flexibility, obvious molecular imprinting effects, and extremely fast template binding kinetics (the semihollow MIP microcapsules without PHEMA brushes reaching equilibrium binding within 1 min). Furthermore, the pH-responsiv…

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Metadata

Authors
Zhou, Y., Mu, Y., & Zhang, H.
Venue
ACS Applied Materials & Interfaces
Publisher
American Chemical Society (ACS)
Published
2025-11-20
Volume
17
Issue
48
Pages
65495-65508
ISSN
  • 1944-8244
  • 1944-8252
DOI
10.1021/acsami.5c19502
Cited by
3
References
0
Language
en
Licence
Funders
National Natural Science Foundation of China (21574070, 22071121)

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