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Cited by 304

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

One-Step Synthesis of Water-Soluble MoS2 Quantum Dots via a Hydrothermal Method as a Fluorescent Probe for Hyaluronidase Detection

Gu, Wei, Yan, Yinghan, Zhang, Cuiling, Ding, Caiping, Xian, Yuezhong·2016·ACS Applied Materials & Interfaces

Abstract

In this work, a bottom-up strategy is developed to synthesize water-soluble molybdenum disulfide quantum dots (MoS2 QDs) through a simple, one-step hydrothermal method using ammonium tetrathiomolybdate [(NH4)2MoS4] as the precursor and hydrazine hydrate as the reducing agent. The as-synthesized MoS2 QDs are few-layered with a narrow size distribution, and the average diameter is about 2.8 nm. The resultant QDs show excitation-dependent blue fluorescence due to the polydispersity of the QDs. Moreover, the fluorescence can be quenched by hyaluronic acid (HA)-functionalized gold nanoparticles through a photoinduced electron-transfer mechanism. Hyaluronidase (HAase), an endoglucosidase, can cleave HA into proangiogenic fragments and lead to the aggregation of gold nanoparticles. As a result, the electron transfer is blocked and fluorescence is recovered. On the basis of this principle, a novel fluorescence sensor for HAase is developed with a linear range from 1 to 50 U/mL and a detection limit of 0.7 U/mL.

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Crossref · 10.1021/acsami.6b01166

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Metadata

Authors
Gu, W., Yan, Y., Zhang, C., Ding, C., & Xian, Y.
Venue
ACS Applied Materials & Interfaces
Published
2016-04-26
Volume
8
Issue
18
Pages
11272-11279
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2336170862
Cited by
304
References
46
FWCI
17.03
Type
journal article
Language
en
Open access
closed

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