The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Fluorescent Carbon Quantum Dots with Intrinsic Nucleolus-Targeting Capability for Nucleolus Imaging and Enhanced Cytosolic and Nuclear Drug Delivery
Abstract
Nucleolus tracking and nucleus-targeted photodynamic therapy are attracting increasing attention due to the importance of nucleolus and the sensitivity of nucleus to various therapeutic stimuli. Herein, a new class of multifunctional fluorescent carbon quantum dots (or carbon dots, CDs) synthesized via the one-pot hydrothermal reaction of m-phenylenediamine and l-cysteine was reported to effectively target nucleolus. The as-prepared CDs possess superior properties, such as low-cost and facile synthesis, good water dispersibility, various surface groups for further modifications, prominent photostability, excellent compatibility, and rapid/convenient/wash-free staining procedures. Besides, as compared with SYTO RNASelect (a commonly used commercial dye for nucleolus imaging) that can only image nucleolus in fixed cells, the CDs can realize high-quality nucleolus imaging in not only fixed cells but also living cells, allowing the real-time tracking of nucleolus-related biological behaviors. Furthermore, after conjugating with protoporphyrin IX (PpIX), a commonly used photosensitizer, the resultant CD-PpIX nanomissiles showed remarkably increased cellular uptake and nucleus-targeting properties and achieved greatly enhanced phototherapeutic efficiency because the nuclei show poor tolerance to reactive oxygen species produced during the photodynamic therapy. The in vivo experiments revealed that the negatively charged CD-PpIX nanomissiles could rapidly and specifically target a tumor site after intravenous injection and cause efficient tumor ablation with no toxic side effects after laser irradiation. It is believed that the present CD-based nanosystem will hold great potential in nucleolus imaging and nucleus-targeted drug delivery and cancer therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Metal-free efficient photocatalyst for stable visible water splitting via a two-electron pathway
Liu, J., Liu, Y., Liu, N., Han, Y., Zhang, X., Huang, H., Lifshitz, Y., Lee, S.-T., Zhong, J., & Kang, Z. (2015) · Science · doi:10.1126/science.aaa3145 · Cited by 4,468
Water‐Soluble Fluorescent Carbon Quantum Dots and Photocatalyst Design
Li, H., He, X., Kang, Z., Huang, H., Liu, Y., Liu, J., Lian, S., Tsang, C. H. A., Yang, X., & Lee, S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906154 · Cited by 2,629
Full-Color Light-Emitting Carbon Dots with a Surface-State-Controlled Luminescence Mechanism
Ding, H., Yu, S.-B., Wei, J.-S., & Xiong, H.-M. (2016) · ACS Nano · doi:10.1021/acsnano.5b05406 · Cited by 2,530
Nanotechnology for Multimodal Synergistic Cancer Therapy
Fan, W., Yung, B., Huang, P., & Chen, X. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00258 · Cited by 1,791
Pan, L., He, Q., Liu, J., Chen, Y., Ma, M., Zhang, L., & Shi, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja211035w · Cited by 984
Sun, D., Ban, R., Zhang, P.-H., Wu, G.-H., Zhang, J.-R., & Zhu, J.-J. (2013) · Carbon · doi:10.1016/j.carbon.2013.07.095 · Cited by 857
Near‐Infrared Photoluminescent Polymer–Carbon Nanodots with Two‐Photon Fluorescence
Lu, S., Sui, L., Liu, J., Zhu, S., Chen, A., Jin, M., & Yang, B. (2017) · Advanced Materials · doi:10.1002/adma.201603443 · Cited by 842
Multifunctional Gold Nanoparticle−Peptide Complexes for Nuclear Targeting
Tkachenko, A. G., Xie, H., Coleman, D., Glomm, W., Ryan, J., Anderson, M. F., Franzen, S., & Feldheim, D. L. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0296935 · Cited by 794
Tao, H., Yang, K., Ma, Z., Wan, J., Zhang, Y., Kang, Z., & Liu, Z. (2012) · Small · doi:10.1002/smll.201101706 · Cited by 732
Kang, B., Mackey, M. A., & El-Sayed, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9102698 · Cited by 674
Cited by
Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications
Liu, J., Li, R., & Yang, B. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c01306 · Cited by 1,936
Carbon-based nanomaterials as an emerging platform for theranostics
Patel, K. D., Singh, R. K., & Kim, H.-W. (2019) · Materials Horizons · doi:10.1039/c8mh00966j · Cited by 555
Carbon quantum dots: Preparation, optical properties, and biomedical applications
Yang, H.-L., Bai, L.-F., Geng, Z.-R., Chen, H., Xu, L.-T., Xie, Y.-C., Wang, D.-J., Gu, H.-W., & Wang, X.-M. (2023) · Materials Today Advances · doi:10.1016/j.mtadv.2023.100376 · Cited by 409
Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots
Anwar, S., Ding, H., Xu, M., Hu, X., Li, Z., Wang, J., Liu, L., Jiang, L., Wang, D., Dong, C., et al. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00112 · Cited by 367
Emerging materials for hemostasis
Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164
Self-citation
Metadata
- Authors
- Hua, X.-W., Bao, Y.-W., & Wu, F.-G.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-03-06
- Volume
- 10
- Issue
- 13
- Pages
- 10664-10677
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2792453304
- Cited by
- 339
- References
- 66
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fluorescent Carbon Quantum Dots with Intrinsic Nucleolus-Targeting Capability for Nucleolus Imaging and Enhanced Cytosolic and Nuclear Drug Delivery. https://app.cochat.ai/papers/10.1021/acsami.7b19549
- The paper
- Hua, X.-W., Bao, Y.-W., & Wu, F.-G. (2018). Fluorescent Carbon Quantum Dots with Intrinsic Nucleolus-Targeting Capability for Nucleolus Imaging and Enhanced Cytosolic and Nuclear Drug Delivery. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.7b19549
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
