Adhesive and Antioxidant Hydrogel with Glucose/ROS Dual-Responsive Drug Release for Diabetic Oral Mucosal Wound Healing
Abstract
Diabetes mellitus is a global health threat, with chronic wounds, including oral mucosal wounds, being a severe complication. These wounds are characterized by delayed healing and increased inflammation due to hyperglycemia, affecting patients' quality of life. Current treatments for oral mucosal wounds cannot offer sustained management of these injuries in diabetic patients. Here, a glucose/ROS dual-responsive hydrogel incorporating sitagliptin was developed for the treatment of diabetic oral mucosal wounds. After chemical modification of tetra-armed poly(ethylene glycol) succinimidyl glutarate (tetra-PEG-SG) by dopamine (DA) and tetra-armed poly(ethylene glycol) amine (tetra-PEG-NH 2 ) by phenylboronic acid (PBA), the resulting hydrogel was capable of rapid gelation, robust tissue adhesion, self-healing, antioxidant capacity, and dual response to glucose and reactive oxygen species (ROS), enabling the feasible injection and stable adherence in the moist oral environment while ensuring sustained therapeutic sitagliptin release. In vivo experiments on oral mucosal defects in diabetic mice revealed that the sitagliptin-loaded hydrogel could effectively reduce inflammation and promote wound healing. Collectively, this finding identifies a potential wound dressing as a therapeutic strategy for diabetic oral mucosal wounds.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The catechol moieties of PDA impart strong wet-tissue adhesive properties to the hydrogel, allowing stable attachment to irregular and saliva-covered mucosal wounds, resistance to mechanical displacement, and the formation of a durable physical barrier.
“The catechol moieties of PDA impart strong wet-tissue adhesive properties to the hydrogel, allowing stable attachment to irregular and saliva-covered mucosal wounds, resistance to mechanical displacement, and the formation of a durable physical barrier.52”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [52]
Cited by
Sorted by citations
Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
- Authors
- Yu, Y., Zhang, M., Li, J., Liu, Z., Lyu, L., Xiao, Y., Yang, G., Liu, J., Wang, Q., Ding, X., Zhang, T., Wang, Y., Wang, X., Yu, T., & Liu, D.
- Affiliations
- National Medical Products Administration (CN)
- Chinese Academy of Sciences (CN)
- Department of Orthodontics
- Corresponding author
- Wang, Xing
- Yu, Tingting
- Liu, Dawei
- ORCID
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2025-03-27
- Volume
- 11
- Issue
- 4
- Pages
- 2321-2337
- ISSN
- 2373-9878 (ISSN-L)
- OpenAlex
- W4408903336
- Cited by
- 12
- References
- 0
- Citations by year
- 2026: 6 · 2025: 6
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2022YFA1206100)
- Key Research and Development Program of Ningxia (2020BCG01001)
- Natural Science Foundation of Beijing Municipality (L222116)
- National Natural Science Foundation of China (52373123, 52373162, 81970909, 82271009)
- National Program for Multidisciplinary Cooperative Treatment on Major Diseases (PKUSSNMP202020)
- Young Scientists Fund of PKUSS (20110203, 20170109)
- China Oral Health Foundation (A2021057)
- Peking University Medicine Seed Fund for Interdisciplinary Research (BMU2018MX007)
- New Clinical Technology Fund of Peking University School of Stomatology (PKUSSNCT-20A07)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- glucose-responsive hydrogels, reactive oxygen species-responsive hydrogel, sitagliptin, wound dressings, tissue adhesion, self-healing hydrogels, antioxidant hydrogel, phenylboronic acid, dopamine, wound healing, inflammation reduction, hyperglycemia
- MeSH terms
- Sitagliptin Phosphate, Adhesives, Animals, Antioxidants, Diabetes Mellitus, Experimental, Glucose, Humans, Male, Mice, Inbred C57BL, Mouth Mucosa, Polyethylene Glycols, Wound Healing, Reactive Oxygen Species, Hydrogels, Mice, Drug Liberation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
