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A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury
Open accessAbstract
). Dose-dependent studies reveal that Ru265 is more potent than the currently employed MCU inhibitor Ru360. Site-directed mutagenesis of Cys97 in the N-terminal domain of human MCU ablates the inhibitory activity of Ru265, suggesting that this matrix-residing domain is its target site. Additionally, Ru265 prevented hypoxia/reoxygenation injury and subsequent mitochondrial dysfunction, demonstrating that this new inhibitor is a valuable tool for studying the functional role of the MCU in intact biological models.
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Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
Mitochondria as sensors and regulators of calcium signalling
Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781
The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability
Luongo, T. S., Lambert, J. P., Gross, P., Nwokedi, M., Lombardi, A. A., Shanmughapriya, S., Carpenter, A. C., Kolmetzky, D., Gao, E., van Berlo, J. H., et al. (2017) · Nature · doi:10.1038/nature22082 · Cited by 396
Self-citationLuongo, T. S., Lambert, J. P., Yuan, A., Zhang, X., Gross, P., Song, J., Shanmughapriya, S., Gao, E., Jain, M., Houser, S. R., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.017 · Cited by 384
Self-citationSPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore
Shanmughapriya, S., Rajan, S., Hoffman, N. E., Higgins, A. M., Tomar, D., Nemani, N., Hines, K. J., Smith, D. J., Eguchi, A., Vallem, S., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.009 · Cited by 209
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Mitochondrial calcium exchange in physiology and disease
Garbincius, J. F., & Elrod, J. W. (2022) · Physiological Reviews · doi:10.1152/physrev.00041.2020 · Cited by 412
Dong, Z., Wang, J., Qiu, T., Wu, J., An, Y., Shi, X., Sun, X., Jiang, L., Liu, X., Yang, G., et al. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153933 · Cited by 41
Huntington, T. E., & Srinivasan, R. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102383 · Cited by 31
Damacena de Angelis, C., Endoni, B. T., Nuno, D., Lamping, K., Ledolter, J., Koval, O. M., & Grumbach, I. M. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023912 · Cited by 17
Metadata
- Authors
- Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J., & Madesh, M.
- Venue
- ACS Central Science
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-01-04
- Volume
- 5
- Issue
- 1
- Pages
- 153-166
- ISSN
- 2374-7943 (ISSN-L)
- 2374-7951
- OpenAlex
- W2908467301
- Cited by
- 161
- References
- 5
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury. https://app.cochat.ai/papers/10.1021/acscentsci.8b00773
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- Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J., & Madesh, M. (2019). A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury. ACS Central Science. https://doi.org/10.1021/acscentsci.8b00773
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
