The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant
Abstract
Clinically, methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection inevitably induces the failure of bone implants. Herein, a hydrophilic and viscous hydrogel of poly(vinyl alcohol) modified with chitosan, polydopamine, and NO release donor was formed on a red phosphorus nanofilm deposited on a titanium implant (Ti-RP/PCP/RSNO). Under the irradiation of near-infrared light (NIR), peroxynitrite ( • ONOO – ) was formed by the reaction between the released NO and superoxide ( • O 2 – ) produced by the RP nanofilm. Specifically, we revealed the antibacterial mechanism of the ONOO – against the MRSA biofilm. In addition, osteogenic differentiation was promoted and inflammatory polarization was regulated by the released NO without NIR irradiation through upregulating the expression of Opn and Ocn genes and TNF-α. The MRSA biofilm was synergistically eradicated by • ONOO –, hyperthermia, and • O 2– under NIR irradiation as well as the immunoreaction of the M1 polarization. The in vivo results also confirmed the excellent osteogenesis and biofilm eradication by released NO from the RP/PCP/RSNO system under NIR irradiation, indicating the noninvasive tissue reconstruction of MRSA-infected tissues through phototherapy and immunotherapy.
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Bai, L., Du, Z., Du, J., Yao, W., Zhang, J., Weng, Z., Liu, S., Zhao, Y., Liu, Y., Zhang, X., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.010 · Cited by 265
Cited by
Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications
Ran, B., Ran, L., Wang, Z., Liao, J., Li, D., Chen, K., Cai, W., Hou, J., & Peng, X. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00326 · Cited by 357
Graphitic carbon nitride-based materials for photocatalytic antibacterial application
Kong, X., Liu, X., Zheng, Y., Chu, P. K., Zhang, Y., & Wu, S. (2021) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2021.100610 · Cited by 259
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Metadata
- Authors
- Li, Y., Liu, X., Li, B., Zheng, Y., Han, Y., Chen, D.-F., Yeung, K. W. K., Cui, Z., Liang, Y., Li, Z., Zhu, S., Wang, X., & Wu, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-06-25
- Volume
- 14
- Issue
- 7
- Pages
- 8157-8170
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3037214868
- Cited by
- 225
- References
- 1
- FWCI
- 26.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Y., Liu, X., Li, B., Zheng, Y., Han, Y., Chen, D.-F., Yeung, K. W. K., Cui, Z., Liang, Y., Li, Z., Zhu, S., Wang, X., & Wu, S. (2020). Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant. ACS Nano. https://doi.org/10.1021/acsnano.0c01486
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