Apolipoprotein E binding drives structural and compositional rearrangement of mRNA-containing lipid nanoparticles

Sebastiani, Federica, Yanez Arteta, Marianna, Lerche, Michael, Porcar, Lionel, Lang, Christian, Bragg, Ryan A., Elmore, Charles S., Krishnamurthy, Venkata R. +9 more·2021·ACS Nano

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  12. Design principles of lipid nanoparticles for RNA delivery
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  13. Development of Lipid Nanoparticles for the Delivery of Macromolecules Based on the Molecular Design of pH-Sensitive Cationic Lipids
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    Linsey J. F. Peters, Alexander Jans, Matthias Bartneck, Emiel P. C. van der Vorst · 2021 · Journal of Clinical Medicine
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