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Nanocomposite Membranes Enhance Bone Regeneration Through Restoring Physiological Electric Microenvironment
Abstract
Physiological electric potential is well-known for its indispensable role in maintaining bone volume and quality. Although implanted biomaterials simulating structural, morphological, mechanical, and chemical properties of natural tissue or organ has been introduced in the field of bone regeneration, the concept of restoring physiological electric microenvironment remains ignored in biomaterials design. In this work, a flexible nanocomposite membrane mimicking the endogenous electric potential is fabricated to explore its bone defect repair efficiency. BaTiO3 nanoparticles (BTO NPs) were first coated with polydopamine. Then the composite membranes are fabricated with homogeneous distribution of Dopa@BTO NPs in poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) matrix. The surface potential of the nanocomposite membranes could be tuned up to -76.8 mV by optimizing the composition ratio and corona poling treatment, which conform to the level of endogenous biopotential. Remarkably, the surface potential of polarized nanocomposite membranes exhibited a dramatic stability with more than half of original surface potential remained up to 12 weeks in the condition of bone defect. In vitro, the membranes encouraged bone marrow mesenchymal stem cells (BM-MSCs) activity and osteogenic differentiation. In vivo, the membranes sustainably maintained the electric microenvironment giving rise to rapid bone regeneration and complete mature bone-structure formation. Our findings evidence that physiological electric potential repair should be paid sufficient attention in biomaterials design, and this concept might provide an innovative and well-suited strategy for bone regenerative therapies.
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Cites
Generation of electric potentials by bone in response to mechanical stress
Bassett, C. A. L., & Becker, R. O. (1962) · Science · doi:10.1126/science.137.3535.1063 · Cited by 778
Cited by
Liu, Z., Wan, X., Wang, Z. L., & Li, L. (2021) · Advanced Materials · doi:10.1002/adma.202007429 · Cited by 478
Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair
Tandon, B., Blaker, J. J., & Cartmell, S. H. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.026 · Cited by 420
Shuai, C., Liu, G., Yang, Y., Qi, F., Peng, S., Yang, W., He, C., Wang, G., & Qian, G. (2020) · Nano Energy · doi:10.1016/j.nanoen.2020.104825 · Cited by 406
Biodegradable materials for bone defect repair
Wei, S., Ma, J.-X., Xu, L., Gu, X.-S., & Ma, X.-L. (2020) · Military Medical Research · doi:10.1186/s40779-020-00280-6 · Cited by 406
Surmenev, R. A., Orlova, T., Chernozem, R. V., Ivanova, A. A., Bartasyte, A., Mathur, S., & Surmeneva, M. A. (2019) · Nano Energy · doi:10.1016/j.nanoen.2019.04.090 · Cited by 357
Metadata
- Authors
- Zhang, X., Zhang, C., Lin, Y., Hu, P., Shen, Y., Wang, K., Meng, S., Chai, Y., Dai, X., Liu, X., Liu, Y., Mo, X., Cao, C., Li, S., Deng, X., & Chen, L.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-07-13
- Volume
- 10
- Issue
- 8
- Pages
- 7279-7286
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2466698266
- Cited by
- 327
- References
- 1
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, X., Zhang, C., Lin, Y., Hu, P., Shen, Y., Wang, K., Meng, S., Chai, Y., Dai, X., Liu, X., Liu, Y., Mo, X., Cao, C., Li, S., Deng, X., & Chen, L. (2016). Nanocomposite Membranes Enhance Bone Regeneration Through Restoring Physiological Electric Microenvironment. ACS Nano. https://doi.org/10.1021/acsnano.6b02247
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