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Cited by 29Iron Metabolism and DisordersMetalloenzymes and iron-sulfur proteinsBacterial Genetics and Biotechnology

Dps Functions as a Key Player in Bacterial Iron Homeostasis

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Williams, Sunanda Margrett, Chatterji, Dipankar·2023·ACS Omega
DOI 10.1021/acsomega.3c03277PMC PMC10536872
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Abstract

Iron plays a vital role in the maintenance of life, being central to various cellular processes, from respiration to gene regulation. It is essential for iron to be stored in a nontoxic and readily available form. DNA binding proteins under starvation (Dps) belong to the ferritin family of iron storage proteins and are adept at storing iron in their hollow protein shells. Existing solely in prokaryotes, these proteins have the additional functions of DNA binding and protection from oxidative stress. Iron storage proteins play a functional role in storage, release, and transfer of iron and therefore are central to the optimal functioning of iron homeostasis. Here we review the multifarious properties of Dps through relevant biochemical and structural studies with a focus on iron storage and ferroxidation. We also examine the role of Dps as a possible candidate as an iron donor to iron-sulfur (Fe-S) clusters, which are ubiquitous to many biological processes.

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  • When grown with an abundance of iron, the cell may sequester iron in hollow multimeric proteins (ferritin, mini-ferritins, and bacterioferritins).

    “When grown with an abundance of iron, the cell may sequester iron in hollow multimeric proteins (ferritin,126,127 mini-ferritins,128 and bacterioferritins129) (Figure 5).”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [128]

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Cited by

Sorted by citations

Authors
Williams, S. M., & Chatterji, D.
Affiliations
  • Institute of Structural and Molecular Biology (GB)
  • Indian Institute of Science Bangalore (IN)
Corresponding author
  • Williams, Sunanda Margrett
  • Chatterji, Dipankar
ORCID
Venue
ACS Omega
Publisher
American Chemical Society (ACS)
Published
2023-09-11
Volume
8
Issue
38
Pages
34299-34309
ISSN
2470-1343 (ISSN-L)
DOI
10.1021/acsomega.3c03277
PMC
PMC10536872
OpenAlex
W4386596745
Cited by
29
References
7
Citations by year
2026: 10 · 2025: 12 · 2024: 7
FWCI
1.40
Type
journal article
Language
en
Open access
Licence
Locations
  • ACS Omega (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
Dps, iron storage protein, iron-sulfur clusters, antioxidant defense, DNA protection

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