A review of small-molecule inhibitors of one-carbon enzymes: SHMT2 and MTHFD2 in the spotlight

Cuthbertson, Christine R., Arabzada, Zahra, Bankhead, Armand, Kyani, Armita, Neamati, Nouri·2021·ACS Pharmacology & Translational Science

Cites (219)

Items 201–219 of 219

  1. Design, synthesis, and enzyme kinetics of novel benzimidazole and quinoxaline derivatives as methionine synthase inhibitors
    Hosam A. Elshihawy, Mohamed A. Helal, Mohamed M. Said, Mohamed A. Hammad · 2013 · Bioorganic & Medicinal Chemistry
  2. Expression level and prospective mechanism of miRNA-99a-3p in head and neck squamous cell carcinoma based on miRNA-chip and miRNA-sequencing data in 1, 167 cases
    Ganguan Wei, Wanping Guo, Zhengyi Tang, Shenghua Li, Huayu Wu, Long-Cheng Zhang · 2019 · Pathology - Research and Practice
  3. Phase I study of AG2034, a targeted GARFT inhibitor, administered once every 3 weeks
    John D. Roberts, Stephen Shibata, DARCY V. SPICER, Howard L. McLeod, Mary Beth Tombes, Brenda Kyle, Mary I. Carroll, Beth Sheedy, Mary A. Collier, Yazdi K. Pithavala et al. · 2000 · Cancer Chemotherapy and Pharmacology
  4. Structure-Activity Relationships
    Robert L. Lipnick · 2020 · CRC Press eBooks
  5. An investigator-initiated phase I study of ONX-0801, a first-in-class alpha folate receptor targeted, small molecule thymidylate synthase inhibitor in solid tumors.
    Udai Banerji, Alvaro Ingles Garces, Vasiliki Michalarea, Ruth R. Ruddle, Florence I. Raynaud, Ruth Riisnaes, Daniel Nava Rodrigues, Nina Tunariu, Joanna C. Porter, Sarah Emily Ward et al. · 2017 · Journal of Clinical Oncology
  6. Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma
    Eric R. Gamazon, Matthew R. Trendowski, Yujia Wen, Claudia Wing, Shannon M. Delaney, Won Huh, Shan Wong, Nancy Jean Cox, M. Eileen Dolan · 2018 · Scientific Reports
  7. Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism
    Tatyana N. Tarasenko, Maxim Jestin, Shingo Matsumoto, Keita Saito, Sean Hwang, Oksana Gavrilova, Niraj S Trivedi, Patricia M. Zerfas, Emanuele Barca, Salvatore DiMauro et al. · 2019 · Journal of Molecular Medicine
  8. Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis
    Manasa Punaha Ravindra, Adrianne Wallace-Povirk, Mohammad Azharul Karim, Mike R. Wilson, Carrie E. O’Connor, Kathryn White, Juiwanna Kushner, Lisa Polin, Christina George, Zhanjun Hou et al. · 2018 · Journal of Medicinal Chemistry
  9. Identification of three new compounds that directly target human serine hydroxymethyltransferase 2
    Yanfang Han, Liping He, Yifei Qi, Yue Zhao, Yue Pan, Bohuan Fang, Sha Li, John Z. H. Zhang, Lujia Zhang · 2020 · Chemical Biology & Drug Design
  10. Discovery of a Potent, Nonpolyglutamatable Inhibitor of Glycinamide Ribonucleotide Transformylase
    Jessica K. DeMartino, Inkyu Hwang, Lan Xu, Ian A. Wilson, Dale L. Boger · 2006 · Journal of Medicinal Chemistry
  11. An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase–ligand complexes following further refinement
    Renata Vieira Bueno, Alice Dawson, William N. Hunter · 2019 · Acta Crystallographica Section F Structural Biology Communications
  12. Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer
    Chun-Hao Chan, Chia-Yu Wu, Navneet Kumar Dubey, Hong-Jian Wei, Jui-Hua Lu, Samantha Mao, Joy N. Liang, Yu-Hsuan Liang, Hsin-Chung Cheng, Win‐Ping Deng · 2020 · Aging
  13. Potent Inhibition of Human Folylpolyglutamate Synthetase by Suramin
    John J. McGuire, William H. Haile · 1996 · Archives of Biochemistry and Biophysics
  14. Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy
    John J. McGuire, Takashi Tsukamoto, Barry P. Hart, James K. Coward, Thomas I. Kalman, John H. Galivan · 1996 · Investigational New Drugs
  15. Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2
    Jana Mládková, Václav Vaněk, Miloš Buděšı́nský, Tomáš Elbert, Zuzana Demianová, Timothy A. Garrow, Jiřı́ Jiráček · 2012 · Journal of Medicinal Chemistry
  16. Design, synthesis and biological activity of N-substituted tetrahydropteroate analogs as non-classical antifolates against cobalamin-dependent methionine synthase and potential anticancer agents
    Meng Wang, Chao Tian, Liangmin Xue, Hao Li, Jing Cong, Fang Fang, Jiajia Yang, Mengmeng Yuan, Ying Chen, Ying Qing Guo et al. · 2020 · European Journal of Medicinal Chemistry
  17. Design, synthesis and activities of aziridine derivatives of N5-methyltetrahydrofolate against methionine synthase
    Xiling Deng, Ying Qing Guo, Chao Tian, Junyi Liu, Xiaowei Wang, Zhili Zhang · 2015 · Chemical Research in Chinese Universities
  18. Specificity and mechanism of the inhibition by cysteamine of the renal glycine-cleavage complex
    Martin Lowry, Michael Stephen Hall, John T. Brosnan · 1986 · Biochemical Society Transactions
  19. Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis
    Weiguo Xiang, Aamod S. Dekhne, Arpit Doshi, Carrie E. O’Connor, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee · 2019 · Bioorganic & Medicinal Chemistry