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Size-Dependent Cell Uptake of Protein-Coated Graphene Oxide Nanosheets
Abstract
As an emerging applied material, graphene has shown tremendous application potential in many fields, including biomedicine. However, the biological behavior of these nanosheets, especially their interactions with cells, is not well understood. Here, we report our findings about the cell surface adhesion, subcellular locations, and size-dependent uptake mechanisms of protein-coated graphene oxide nanosheets (PCGO). Small nanosheets enter cells mainly through clathrin-mediated endocytosis, and the increase of graphene size enhances phagocytotic uptake of the nanosheets. These findings will facilitate biomedical and toxicologic studies of graphenes and provide fundamental understanding of interactions at the interface of two-dimensional nanostructures and biological systems.
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Citations
Cited by
Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Nanotoxicity of Graphene and Graphene Oxide
Seabra, A. B., Paula, A. J., de Lima, R., Alves, O. L., & Durán, N. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400385x · Cited by 893
Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering
Zhao, H., Ding, R., Zhao, X., Li, Y., Qu, L., Pei, H., Yildirimer, L., Wu, Z., & Zhang, W. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.04.002 · Cited by 336
Rhazouani, A., Gamrani, H., El Achaby, M., Aziz, K., Gebrati, L., Uddin, M. S., & AZIZ, F. (2021) · BioMed Research International · doi:10.1155/2021/5518999 · Cited by 221
Metadata
- Authors
- Mu, Q., Su, G., Li, L., Gilbertson, B. O., Yu, L. H., Zhang, Q., Sun, Y.-P., & Yan, B.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-03-23
- Volume
- 4
- Issue
- 4
- Pages
- 2259-2266
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2030730002
- Cited by
- 361
- References
- 0
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mu, Q., Su, G., Li, L., Gilbertson, B. O., Yu, L. H., Zhang, Q., Sun, Y.-P., & Yan, B. (2012). Size-Dependent Cell Uptake of Protein-Coated Graphene Oxide Nanosheets. ACS Applied Materials & Interfaces. https://doi.org/10.1021/am300253c
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