The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Cobalamin-Dependent Methyltransferases
Abstract
Cobalamin cofactors play critical roles in radical-catalyzed rearrangements and in methyl transfers. This Account focuses on the role of methylcobalamin and its structural homologues, the methylcorrinoids, as intermediaries in methyl transfer reactions, and particularly on the reaction catalyzed by cobalamin-dependent methionine synthase. In these methyl transfer reactions, the cobalt(I) form of the cofactor serves as the methyl acceptor. Biological methyl donors to cobalamin include N5-methyltetrahydrofolate, other methylamines, methanol, aromatic methyl ethers, acetate, and dimethyl sulfide. The challenge for chemists is to determine the enzymatic mechanisms for activation of these unreactive methyl donors and to mimic these amazing biological reactions.
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Cites
Chemistry and biochemistry of B12
Banerjee, R. V. (1999) · Cited by 713
How a Protein Binds B 12 : A 3.0 Å X-Ray Structure of B 12 -Binding Domains of Methionine Synthase
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Self-citationThe electrochemistry of vitamin B12
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Self-citationMethylcobamide:Coenzyme M Methyltransferase Isozymes from Methanosarcina barkeri
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Methanol: Coenzyme M Methyltransferase from Methanosarcina Barkeri
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Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase
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Self-citationO‐Demethylase from Acetobacterium dehalogenans
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Cited by
Review: Biological methylation of less-studied elements
Thayer, J. S. (2002) · Applied Organometallic Chemistry · doi:10.1002/aoc.375 · Cited by 112
Anderson, P. J., Lango, J., Carkeet, C., Britten, A., Kräutler, B., Hammock, B. D., & Roth, J. R. (2008) · Journal of Bacteriology · doi:10.1128/jb.01386-07 · Cited by 63
A critical role for B-vitamin nutrition in human developmental and evolutionary biology
Lucock, M., Yates, Z., Glanville, T., Leeming, R., Simpson, N., & Daskalakis, I. (2003) · Nutrition Research · doi:10.1016/s0271-5317(03)00156-8 · Cited by 47
On the evolution of coenzyme biosynthesis
Kirschning, A. (2022) · Natural Product Reports · doi:10.1039/d2np00037g · Cited by 37
Synergy of genes and nutrients: the case of homocysteine
Lucock, M. D. (2006) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/01.mco.0000247468.18790.1e · Cited by 24
Metadata
- Authors
- Matthews, R. G.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-05-24
- Volume
- 34
- Issue
- 8
- Pages
- 681-689
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2138516874
- Cited by
- 285
- References
- 16
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
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