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Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog
Abstract
In 1893, P. Biginelli reported the synthesis of functionalized 3, 4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde, urea, and ethyl acetoacetate. In the past decade, this long-neglected multicomponent reaction has experienced a remarkable revival, mainly due to the interesting pharmacological properties associated with this dihydropyrimidine scaffold. In this Account, we highlight recent developments in the Biginelli reaction in areas such as solid-phase synthesis, combinatorial chemistry, and natural product synthesis.
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Cited by
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Gawande, M. B., Bonifácio, V. D. B., Luque, R., Branco, P. S., & Varma, R. S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60025d · Cited by 674
Solvent-Free Heterocyclic Synthesis
Martins, M. A. P., Frizzo, C. P., Moreira, D. N., Buriol, L., & Machado, P. (2009) · Chemical Reviews · doi:10.1021/cr9001098 · Cited by 638
Singh, M. S., & Chowdhury, S. (2012) · RSC Advances · doi:10.1039/c2ra01056a · Cited by 506
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Metadata
- Authors
- Kappe, C. O.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-09-28
- Volume
- 33
- Issue
- 12
- Pages
- 879-888
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2127457669
- Cited by
- 1,104
- References
- 0
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- closed
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