The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Direct Catalytic Asymmetric Mannich Reaction
Abstract
The direct catalytic asymmetric addition of unmodified carbonyl compounds to preformed or in situ-generated imines has emerged as a promising new route to optically enriched alpha- and beta-amino acid derivatives, beta-lactams, and 1,2- and gamma-amino alcohols. The direct catalytic asymmetric Mannich reactions are mediated by small organometallic and organic amine catalysts that can achieve levels of selectivity similar to those possible with natural enzymes. The different small-molecule catalysts described here are complementary in their applications. They also complement each other in syn or anti selectivity of the direct asymmetric Mannich reaction. In this Account, we highlight the recent developments in and contributions to this research.
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Citations
Cites
The Atom Economy—A Search for Synthetic Efficiency
Trost, B. (1991) · Science · doi:10.1126/science.1962206 · Cited by 4,798
Proline-catalyzed asymmetric reactions
List, B. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00516-1 · Cited by 1,154
Enantioselective Organocatalysis
Dalko, P. I., & Moisan, L. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20011015)40:20<3726::aid-anie3726>3.0.co;2-d · Cited by 1,127
Nixon, J. F. (1982) · Journal of Organometallic Chemistry · doi:10.1016/s0022-328x(00)85867-2 · Cited by 1,077
New Type of Asymmetric Cyclization to Optically Active Steroid CD Partial Structures
Eder, U., Sauer, G., & Wiechert, R. (1971) · Angewandte Chemie International Edition in English · doi:10.1002/anie.197104961 · Cited by 1,057
Amino acids and peptides as asymmetric organocatalysts
Jarvo, E. R., & Miller, S. J. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00122-9 · Cited by 655
Catalytic Asymmetric Synthesis of anti-1,2-Diols
Notz, W., & List, B. (2000) · Journal of the American Chemical Society · doi:10.1021/ja001460v · Cited by 645
Wenzel, A. G., & Jacobsen, E. N. (2002) · Journal of the American Chemical Society · doi:10.1021/ja028353g · Cited by 564
Duthaler, R. O. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390283 · Cited by 284
Manabe, K., & Kobayashi, S. (1999) · Organic Letters · doi:10.1021/ol991113u · Cited by 207
Cited by
Hayashi, Y., Matsuzawa, M., Yamaguchi, J., Yonehara, S., Matsumoto, Y., Shoji, M., Hashizume, D., & Koshino, H. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601506 · Cited by 120
Metadata
- Authors
- Córdova, A.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-01-13
- Volume
- 37
- Issue
- 2
- Pages
- 102-112
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2130810591
- Cited by
- 747
- References
- 11
- FWCI
- 41.52
- Type
- journal article
- Language
- en
- Open access
- closed
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