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Unlocking the Potential of Asymmetric Hydrogenation at Merck
Abstract
This Account outlines the efforts of Merck scientists toward implementing asymmetric hydrogenation as a core competency within Merck Research Laboratories. Several key factors are discussed including (i) a focus on efficient chemical synthesis, (ii) implementation of high throughput screening (HTS) techniques, (iii) demonstration of robustness on scale, and (iv) diligence to ensure freedom of operation and catalyst supply for manufacturing. Several examples of the development of efficient asymmetric hydrogenation processes are described.
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Citations
Cited by
Tay, N. E. S., Lehnherr, D., & Rovis, T. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00384 · Cited by 518
Dub, P. A., & Ikariya, T. (2012) · ACS Catalysis · doi:10.1021/cs300341g · Cited by 386
Machine learning dihydrogen activation in the chemical space surrounding Vaska's complex
Friederich, P., dos Passos Gomes, G., De Bin, R., Aspuru-Guzik, A., & Balcells, D. (2020) · Chemical Science · doi:10.1039/d0sc00445f · Cited by 179
Metadata
- Authors
- Shultz, C. S., & Krska, S. W.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-20
- Volume
- 40
- Issue
- 12
- Pages
- 1320-1326
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2089077832
- Cited by
- 195
- References
- 0
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Unlocking the Potential of Asymmetric Hydrogenation at Merck. https://app.cochat.ai/papers/10.1021/ar700141v
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- Shultz, C. S., & Krska, S. W. (2007). Unlocking the Potential of Asymmetric Hydrogenation at Merck. Accounts of Chemical Research. https://doi.org/10.1021/ar700141v
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
