The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Selective Fluoroalkylations with Fluorinated Sulfones, Sulfoxides, and Sulfides
Abstract
Efficient fluoroalkylations have been proven to be a highly useful strategy for the synthesis of bioactive fluorine-containing compounds and other materials. The design and use of a single category of reagents for multiple synthetic goals are much more attractive to preparative organic chemists. In this Account, we show how we have succeeded in the nucleophilic trifluoromethylation, difluoromethylation, difluoromethylenation, (phenylsulfonyl)difluoromethylation, (phenylthio)difluoromethylation, and monofluoromethylation as well as radical (phenylsulfonyl)difluoromethylation and electrophilic difluoromethylation by using fluorinated sulfones, sulfoxides, sulfides, or fluorinated sulfonium salts. The chemistry not only provides practically powerful synthetic methods, but the molecular design concept that we have developed may also be adopted to tackle other related chemical problems.
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Cites
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Self-citationOrganofluorine Compounds: Chemistry and Applications
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Self-citationDie ersten CF3-substituierten organyl(chlor)silane
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Cited by
The Many Roles for Fluorine in Medicinal Chemistry
Hagmann, W. K. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800219f · Cited by 3,578
Recent advances in enantioselective trifluoromethylation reactions
Shibata, N., Mizuta, S., & Kawai, H. (2008) · Tetrahedron: Asymmetry · doi:10.1016/j.tetasy.2008.11.011 · Cited by 347
Recent advances in photoinduced trifluoromethylation and difluoroalkylation
Pan, X., Xia, H., & Wu, J. (2016) · Organic Chemistry Frontiers · doi:10.1039/c6qo00153j · Cited by 283
Desulfonylation via Radical Process: Recent Developments in Organic Synthesis
Chu, X.-Q., Ge, D., Cui, Y.-Y., Shen, Z.-L., & Li, C.-J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00084 · Cited by 259
Metadata
- Authors
- Prakash, G. K. S., & Hu, J.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-08-21
- Volume
- 40
- Issue
- 10
- Pages
- 921-930
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W1968863974
- Cited by
- 383
- References
- 18
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- closed
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