The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Paramagnetic Water-Soluble Metallofullerenes Having the Highest Relaxivity for MRI Contrast Agents
Abstract
Water-soluble gadolinium (Gd) endohedral metallofullerenes have been synthesized as polyhydroxyl forms (Gd@C(82)(OH)(n)(), Gd-fullerenols) and their paramagnetic properties were evaluated by in vivo as well as in vitro for the novel magnetic resonance imaging (MRI) contrast agents for next generation. The in vitro water proton relaxivity, R(1) (the effect on 1/T(1)), of Gd-fullerenols is significantly higher (20-folds) than that of the commercial MRI contrast agent, Magnevist (gadolinium-diethylenetriaminepentaacetic acid, Gd-DTPA) at 1.0 T close to the common field of clinical MRI. This unusually high proton relaxivity of Gd-fullerenols leads to the highest signal enhancement at extremely lower Gd concentration in MRI studies. The strong signal was confirmed in vivo MRI at lung, liver, spleen, and kidney of CDF1 mice after i.v. administration of Gd-fullerenols at a dose of 5 micromol Gd/kg, which was 1/20 of the typical clinical dose (100 micromol Gd/kg) of Gd-DTPA.
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Cites
Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design
Lauffer, R. B. (1987) · Chemical Reviews · doi:10.1021/cr00081a003 · Cited by 1,978
Multi-planar image formation using NMR spin echoes
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Tilcock, C. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00109-4 · Cited by 52
Cited by
Popov, A. A., Yang, S., & Dunsch, L. (2013) · Chemical Reviews · doi:10.1021/cr300297r · Cited by 1,256
Fullerene derivatives: an attractive tool for biological applications
Bosi, S., Da Ros, T., Spalluto, G., & Prato, M. (2003) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2003.09.005 · Cited by 834
Villaraza, A. J. L., Bumb, A., & Brechbiel, M. W. (2010) · Chemical Reviews · doi:10.1021/cr900232t · Cited by 632
Krisanova, N., Kasatkina, L., Sivko, R., Borysov, A., Nazarova, A., Slenzka, K., & Borisova, T. (2013) · Astrobiology · doi:10.1089/ast.2012.0950 · Cited by 33
Metadata
- Authors
- Mikawa, M., Kato, H., Okumura, M., Narazaki, M., Kanazawa, Y., Miwa, N., & Shinohara, H.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-06-27
- Volume
- 12
- Issue
- 4
- Pages
- 510-514
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W1969251429
- Cited by
- 462
- References
- 3
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mikawa, M., Kato, H., Okumura, M., Narazaki, M., Kanazawa, Y., Miwa, N., & Shinohara, H. (2001). Paramagnetic Water-Soluble Metallofullerenes Having the Highest Relaxivity for MRI Contrast Agents. Bioconjugate Chemistry. https://doi.org/10.1021/bc000136m
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