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Functionalized Derivatives of Hyaluronic Acid Oligosaccharides: Drug Carriers and Novel Biomaterials
Abstract
Oligosaccharides derived from hyaluronic acid (HA), a naturally occurring linear polysaccharide composed of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid, can be chemically modified to introduce a pendant amine-like functionality (patent application pending). Covalent attachment of steroidal and nonsteroidal antiinflammatory drugs to functionalized HA oligosaccharides was accomplished with the incorporation of hydrolytically labile bonds. Further derivatization of the pendant group with homobifunctional crosslinkers allowed the introduction of covalent crosslinks. Chemically-modified HA oligosaccharides were unambiguously characterized in solution by high-resolution 1H NMR spectroscopy.
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Citations
Cited by
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Zhao, X., Chen, X., Yuk, H., Lin, S., Liu, X., & Parada, G. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01088 · Cited by 1,161
Schanté, C. E., Zuber, G., Herlin, C., & Vandamme, T. F. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.03.019 · Cited by 708
Bulpitt, P., & Aeschlimann, D. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199911)47:2<152::aid-jbm5>3.0.co;2-i · Cited by 560
Hyaluronan–CD44 interactions as potential targets for cancer therapy
Misra, S., Heldin, P., Hascall, V. C., Karamanos, N. K., Skandalis, S. S., Markwald, R. R., & Ghatak, S. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08071.x · Cited by 494
Li, J., Huo, M., Wang, J., Zhou, J., Mohammad, J. M., Zhang, Y., Zhu, Q., Waddad, A. Y., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.022 · Cited by 468
Metadata
- Authors
- Pouyani, T., & Prestwich, G. D.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-07-01
- Volume
- 5
- Issue
- 4
- Pages
- 339-347
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2026465049
- Cited by
- 216
- References
- 0
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pouyani, T., & Prestwich, G. D. (1994). Functionalized Derivatives of Hyaluronic Acid Oligosaccharides: Drug Carriers and Novel Biomaterials. Bioconjugate Chemistry. https://doi.org/10.1021/bc00028a010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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