The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA
Abstract
The investigation of the three-dimensional structure of the DNA aptamer d(G1G2T3-T4G5G6T7G8T9G10G11T12T13G14G15) which binds to and inhibits thrombin has been carried out by NMR methods. This DNA exhibits a number of long-range NOEs between residues which are not adjacent in sequence, which allowed the determination of the novel tertiary structure adopted. This DNA adopts a highly compact, highly symmetrical structure which consists of two tetrads of guanosine base pairs and three loops. The residues of the tetrads alternate anti-syn-anti-syn. This novel structural motif for DNA may also be relevant to the structure of telomere DNA.
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Citations
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Metadata
- Authors
- Wang, K. Y., McCurdy, S., Shea, R. G., Swaminathan, S., & Bolton, P. H.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1993-03-02
- Volume
- 32
- Issue
- 8
- Pages
- 1899-1904
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2024913717
- Cited by
- 332
- References
- 20
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
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