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Cited by 271

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin

Choi, Eui-Ju, Xia, Zhengui, Storm, Daniel R.·1992·Biochemistry
DOI 10.1021/bi00143a019
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Abstract

Characterization of adenylyl cyclases has been facilitated by the isolation of cDNA clones for distinct adenylyl cyclases including the type I and type III enzymes. Expression of type I adenylyl cyclase activity in animal cells has established that this enzyme is stimulated by calmodulin and Ca2+. Type III adenylyl cyclase is enriched in olfactory neurons and is regulated by stimulatory G proteins. The sensitivity of the type III adenylyl cyclase to Ca2+ and calmodulin has not been reported. In this study, type III adenylyl cyclase was expressed in human kidney 293 cells to determine if the enzyme is stimulated by Ca2+ and calmodulin. The type III enzyme was not stimulated by Ca2+ and calmodulin in the absence of other effectors. It was, however, stimulated by Ca2+ through calmodulin when the enzyme was concomitantly activated by either GppNHp or forskolin. The concentrations of free Ca2+ for half-maximal stimulation of type I and type III adenylyl cyclases were 0.05 and 5.0 microM Ca2+, respectively. These data suggest that the type III adenylyl cyclase is stimulated by Ca2+ when the enzyme is activated by G-protein-coupled receptors and that increases in free Ca2+ accompanying receptor activation may amplify the primary cyclic AMP signal.

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Metadata

Authors
Choi, E.-J., Xia, Z., & Storm, D. R.
Venue
Biochemistry
Publisher
American Chemical Society (ACS)
Published
1992-07-21
Volume
31
Issue
28
Pages
6492-6498
ISSN
  • 0006-2960 (ISSN-L)
  • 1520-4995
DOI
10.1021/bi00143a019
OpenAlex
W1984565480
Cited by
271
References
40
FWCI
10.94
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin. https://app.cochat.ai/papers/10.1021/bi00143a019
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Choi, E.-J., Xia, Z., & Storm, D. R. (1992). Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin. Biochemistry. https://doi.org/10.1021/bi00143a019

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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