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Lateral diffusion in the liquid phases of dimyristoylphosphatidylcholine/cholesterol lipid bilayers: a free volume analysis
Abstract
The technique of fluorescence recovery after photobleaching is used to perform an extensive study of the lateral diffusion of a phospholipid probe in the binary mixture dimyristoylphosphatidylcholine/cholesterol, above the melting temperature of the phospholipid. In the regions of the phase diagram where a single liquid phase exists, diffusion can be quantitatively described by free volume theory, using a modified Macedo-Litovitz hybrid equation. In the liquid-liquid immiscibility region, the temperature dependence of the diffusion coefficient is in excellent agreement with current theories of generalized diffusivities in composite two-phase media. A consistent interpretation of the diffusion data can be provided based essentially on the idea that the primary effect of cholesterol addition to the bilayer is to occupy free volume. On this basis, a general interpretation of the phase behavior of this mixture is also proposed.
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Citations
Cited by
Cholesterol interactions with phospholipids in membranes
Ohvo-Rekilä, H. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00020-0 · Cited by 1,003
London, E., & Brown, D. A. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0304-4157(00)00007-1 · Cited by 688
The differential miscibility of lipids as the basis for the formation of functional membrane rafts
Rietveld, A., & Simons, K. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00019-7 · Cited by 513
Bending elasticities of model membranes: influences of temperature and sterol content
Méléard, P., Gerbeaud, C., Pott, T., Fernandez-Puente, L., Bivas, I., Mitov, M. D., Dufourcq, J., & Bothorel, P. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78905-7 · Cited by 323
A ring to rule them all: the effect of cyclopropane fatty acids on the fluidity of lipid bilayers
Poger, D., & Mark, A. E. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b00958 · Cited by 162
Metadata
- Authors
- Almeida, P. F. F., Vaz, W. L. C., & Thompson, T. E.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-07
- Volume
- 31
- Issue
- 29
- Pages
- 6739-6747
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W1985868705
- Cited by
- 572
- References
- 0
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lateral diffusion in the liquid phases of dimyristoylphosphatidylcholine/cholesterol lipid bilayers: a free volume analysis. https://app.cochat.ai/papers/10.1021/bi00144a013
- The paper
- Almeida, P. F. F., Vaz, W. L. C., & Thompson, T. E. (1992). Lateral diffusion in the liquid phases of dimyristoylphosphatidylcholine/cholesterol lipid bilayers: a free volume analysis. Biochemistry. https://doi.org/10.1021/bi00144a013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
